ArticleSleep medicine2019
White matter structural differences in OSA patients experiencing residual daytime sleepiness with high CPAP use: a non-Gaussian diffusion MRI study.
Article in Sleep medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Impact of CPAP treatment for obstructive sleep apnea on visceral adipose tissue: a meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Trial
- Effects of solriamfetol in a long-term trial of participants with obstructive sleep apnea who are adherent or nonadherent to airway therapy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Trial
- Reply to "Validating the psychomotor vigilance task cutoff for residual excessive daytime sleepiness in treated obstructive sleep apnea".Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Validating the psychomotor vigilance task cutoff for residual excessive daytime sleepiness in treated obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- The micro-structural changes in white matter fibers associated with anxiety and depression in moderate-severe obstructive sleep apnea.Scientific reports · 2026Article
- Cognition and psychomotor vigilance in treated sleep apnea patients with and without daytime sleepiness: the MAGNETO study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Non-Gaussian diffusion MRI models for preoperative assessment of microvascular invasion in hepatocellular carcinoma.Abdominal radiology (New York) · 2026Article
- Cerebral network topology and peak width of skeletonized mean diffusivity changes associated with cognitive impairment in patients with obstructive sleep apnea.Brain imaging and behavior · 2025Article
- Efficacy of armodafinil in moderate to severe obstructive sleep apnea patients with excessive daytime sleepiness after suboptimal usage of continuous positive airway pressure treatment: a prospective study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Clinical characteristics of obstructive sleep apnoea patients with residual sleepiness.ERJ open research · 2025Review
- Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot study with diffusion kurtosis imaging.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Utilization of diffusion-weighted derived mathematical models to predict prognostic factors of resectable rectal cancer.Abdominal radiology (New York) · 2024Article
- Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study.Nature and science of sleep · 2024Article
- Characterization of prostatic cancer lesion and gleason grade using a continuous-time random-walk diffusion model at high b-values.Frontiers in oncology · 2024Article
- The Relationship Between Sleep and Brain Function in Older Adults With Chronic Kidney Disease and Self-Identified Cognitive Impairment.Journal of gerontological nursing · 2023Article
- Obstructive Sleep Apnea - Influence on the Cardiovascular System and Cognition.Laryngo- rhino- otologie · 2023Article
- What respiratory physicians should know about narcolepsy and other hypersomnias.Breathe (Sheffield, England) · 2022Review
- Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Deep Learning Analyses of Brain MRI to Identify Sustained Attention Deficit in Treated Obstructive Sleep Apnea: A Pilot Study.Sleep and vigilance · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo investigate factors associated with residual sleepiness in patients who were highly adherent to continuous positive airway pressure (CPAP). Nocturnal inactivity, comorbidities, concomitant medications, and, in particular, white matter (WM) differences using diffusion magnetic resonance imaging (MRI) were explored using a continuous-time random-walk (CTRW) model.
methodsTwenty-seven male patients (30-55 years of age) with obstructive sleep apnea (OSA) received CPAP as the only treatment (CPAP ≥ 6 h/night) for at least 30 days. Based on the Psychomotor Vigilance Task (PVT) results, participants were divided into a non-sleepy group (lapses ≤ 5; n = 18) and a sleepy group (lapses > 5; n = 9). Mean nocturnal inactivity (sleep proxy) was measured using actigraphy for one week. Diffusion-weighted imaging (DWI) with high b-values, as well as diffusion tensor imaging (DTI), was performed on a 3 T MRI scanner. The DWI dataset was analyzed using the CTRW model that yielded three parameters: temporal diffusion heterogeneity α, spatial diffusion heterogeneity β, and an anomalous diffusion coefficient D
resultsThere were no differences between groups in mean sleep duration, comorbidities, and the number or type of medications, including alerting and sedating medications. In the whole-brain DWI analysis, the sleepy group showed higher α (17.27% of the WM voxels) and D
conclusionsThe observed differences in the CTRW parameters between the two groups indicate that WM alterations can be a possible mechanism to explain reversible versus residual sleepiness observed in OSA patients with identical high level of CPAP use. The moderate to strong correlations between the CTRW parameters and the clinical scores suggest the possibility of developing objective and quantitative imaging markers to complement clinical assessment of OSA patients.
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Registered trials
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