Evidence map›Paper›PMID 30445065›Full record

ArticleThe Journal of allergy and clinical immunology2019

Remission of persistent childhood asthma: Early predictors of adult outcomes.

Alberta L Wang, Soma Datta, Scott T Weiss, Kelan G Tantisira

Abstract readComparative Study
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024
    Review
  9. Article
  10. Article
  11. Early Prediction of Asthma.Journal of clinical medicine · 2023
    Review
  12. Article
  13. Article
  14. Pediatric asthma incidence rates in the United States from 1980 to 2017.The Journal of allergy and clinical immunology · 2021
    Article
  15. Article
  16. Eosinophils and childhood asthma.Clinical and experimental pediatrics · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Alberta L WangChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Soma DattaChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Kelan G TantisiraChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: rekgt@channing.harvard.edu.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
ZOPOLRESTAT PHARMACOKINETICS IN DIABETICS WITH VARYING RENAL FUNCTIONM01RR000051 · NCRR · UNIVERSITY OF COLORADO DENVER · PI ALBERT, RICHARD K · 1985 to 2008
$52.6M
THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMESM01RR000036 · NCRR · WASHINGTON UNIVERSITY · PI REEDS, DOMINIC N · 1985 to 2007
$25.4M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
ZINC THERAPY FOR SCLERODERMA--PHASE I STUDYM01RR002719 · NCRR · JOHNS HOPKINS UNIVERSITY · PI SEO, PHILIP · 1986 to 2007
$20.2M
SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASEST32HL007427 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI DAWN L DEMEO, Edwin K Silverman · 1985 to 2026
$13.6M
IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2M
CAMPCS/3U01HL075408 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2003 to 2010
$4.9M
MICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4M
CAMP Continuation Study/Phase 3U01HL075419 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FUHLBRIGGE, ANNE L · 2003 to 2010
$2.0M
CAMP Continuation Study/Phase 3U01HL075409 · NHLBI · ASTHMA, INC. · PI WILLIAMS, PAUL V · 2003 to 2010
$1.6M
NCATS NIH HHS UL1 TR000154NCRR NIH HHS M01 RR000036NCRR NIH HHS M01 RR000051NCRR NIH HHS M01 RR002719NCRR NIH HHS UL1 RR025780NHLBI NIH HHS N01 HR016044NHLBI NIH HHS R01 HL127332NHLBI NIH HHS R01 HL129935NHLBI NIH HHS T32 HL007427NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01 HL075232NHLBI NIH HHS U01 HL075407NHLBI NIH HHS U01 HL075408NHLBI NIH HHS U01 HL075409NHLBI NIH HHS U01 HL075415NHLBI NIH HHS U01 HL075416NHLBI NIH HHS U01 HL075417NHLBI NIH HHS U01 HL075419NHLBI NIH HHS U01 HL075420NIAID NIH HHS T32 AI007306
6 · The paper itself

Abstract

backgroundFew data exist on the predictors of asthma remission by early adulthood in North America.

objectiveThe predictors of adult asthma remission were determined in a multiethnic population of patients with mild-to-moderate persistent childhood asthma.

methodsAsthma remission in early adulthood was measured by using 2 definitions: a clinical and a strict definition. Both included normal lung function and the absence of symptoms, exacerbations, and medication use. The strict definition also included normal airways responsiveness. Predictors were identified from 23 baseline measures by using multivariate logistic regression. The probability of remission was modeled by using decision tree analysis.

resultsIn 879 subjects the mean ± SD baseline age was 8.8 ± 2.1 years, 59.4% were male, and 68.7% were white. By adulthood, 229 (26.0%) of 879 participants were in clinical remission, and 111 (15.0%) of 741 participants were in strict remission. The degree of FEV

conclusionA considerable minority of patients with persistent childhood asthma will have disease remission by adulthood. Clinical prognostic indicators of asthma remission, including baseline lung function, can be seen from an early age.

Indexed as

AdultAsthmaChildEosinophilsEthnicityFemaleHumansLeukocyte CountMalePredictive Value of TestsPrognosisRespiratory Function TestsRespiratory HypersensitivityTreatment OutcomeUnited Statesasthma remissionPediatric asthmaprognostication

Identifiers

PMID30445065
PMCPMC7061344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.