Evidence map›Paper›PMID 30445052›Full record

ArticleCell chemical biology2018

Weighing up the Selenocysteome Uncovers New Sec-rets.

Jesse R Poganik, Yimon Aye

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jesse R PoganikInstitute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Yimon AyeInstitute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Electronic address: yimon.aye@epfl.ch.

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Deconvoluting Redox Biology with Targeted ChemistryDP2GM114850 · NIGMS · CORNELL UNIVERSITY · PI AYE, YIMON · 2014 to 2014
$2.3M
NIGMS NIH HHS DP2 GM114850NIGMS NIH HHS T32 GM008500
6 · The paper itself

Abstract

Challenging the paradigm of SECIS-dependent selenoprotein translation, in this issue of Cell Chemical BiologyGuo et al. (2018) introduce a new selenoprotein profiling platform with which they identify novel selenoproteins apparently lacking SECIS. With increased interest in covalent targeting of reactive Sec residues in drug discovery, their method adds a valuable contribution toward expanding the druggable human proteome.

Indexed as

SelenocysteineSelenoproteinsHumansMass SpectrometryProteomeProto-Oncogene Proteins c-retProteomeProto-Oncogene Proteins c-retRET protein, humanSelenocysteineSelenoproteins

Identifiers

PMID30445052
PMCPMC6275148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.