Evidence map›Paper›PMID 30445044›Full record

ArticleArchives of biochemistry and biophysics2019

Pathogenic troponin T mutants with opposing effects on myofilament Ca

Karissa M Dieseldorff Jones, Yeojung Koh, Rebecca S Weller, Rajdeep S Turna, Ferhaan Ahmad, Sabine Huke, Björn C Knollmann, Jose Renato Pinto, Hyun Seok Hwang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Nucleus Mechanosensing in Cardiomyocytes.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Karissa M Dieseldorff JonesBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Yeojung KohDepartment of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA.
Rebecca S WellerDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA.
Rajdeep S TurnaBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Ferhaan AhmadDepartment of Internal Medicine University of Iowa, Iowa City, IA, USA.
Sabine HukeDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA; Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Björn C KnollmannDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA.
Jose Renato PintoBiomedical Sciences, Florida State University, Tallahassee, FL, USA.
Hyun Seok HwangDepartment of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA. Electronic address: hhwang2@fsu.edu.
Florida State University · USVanderbilt University · USUniversity of Iowa · US

Funding

Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
Troponin T mutations and Sudden Cardiac DeathR01HL071670 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2003 to 2017
$4.5M
Modulators of Cardiomyopathic DiseasesR01HL128683 · NHLBI · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO · 2016 to 2020
$1.8M
Cardiomyocyte-mediated mechanisms of ischemiaR01HL128563 · NHLBI · VANDERBILT UNIVERSITY · PI PRABHU, SUMANTH D · 2015 to 2018
$1.5M
Reversal of Hypertrophic Cardiomyopathy via Conditional Ablation of Cardiac Myosin Light Chain KinaseF31HL137408 · NHLBI · FLORIDA STATE UNIVERSITY · PI DIESELDORFF JONES, KARISSA M · 2017 to 2019
$105k
NHLBI NIH HHS F31 HL137408NHLBI NIH HHS R01 HL071670NHLBI NIH HHS R01 HL128563NHLBI NIH HHS R01 HL128683NHLBI NIH HHS R35 HL144980
6 · The paper itself

Abstract

Mutations in cardiac troponin T (TnT) associated with hypertrophic cardiomyopathy generally lead to an increase in the Ca

Indexed as

Cardiomyopathy, DilatedEchocardiographyElectrocardiographyMutation, MissenseTroponin TAmino Acid SubstitutionAnimalsArrhythmias, CardiacMiceMice, TransgenicMyofibrilsTroponin TArrhythmiasDilated cardiomyopathyHypertrophic cardiomyopathyMyofilament Ca(2+) sensitivityTroponin T mutations

Identifiers

PMID30445044
PMCPMC6347385
OpenAlexW2901078154

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.