SynthesisContraception2019
Medical abortion in the late first trimester: a systematic review.
Synthesis in Contraception, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Medical methods for first trimester abortion.The Cochrane database of systematic reviews · 2022Pooled it
- Is a history of cesarean section a predictive factor for the failure of medical management in spontaneous abortion?Archives of gynecology and obstetrics · 2026Article
- Post protocol residual thickness as a negative predictor for pharmacological treatment in early pregnancy loss.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- The Sociodemographic Benefits of Extending MS-2Step to 70 Days in Australia.The Australian & New Zealand journal of obstetrics & gynaecology · 2026Article
- Application of narrow-band imaging combined with hysteroscopic 7Fr cold knife in the treatment of missed early miscarriage.Archives of gynecology and obstetrics · 2025Article
- Analysis of the implementation value of abdominal B-ultrasound combined with cervical cerclage in the prevention and treatment of late recurrent spontaneous abortion.BMC pregnancy and childbirth · 2024Article
- Mifepristone as a non-emergency contraceptive among women of reproductive age: a protocol for systematic review and meta-analysis.BMJ open · 2024Article
- Abortion Surveillance - United States, 2022.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2024Article
- Comprehensive Overview of Methods of Pregnancy Termination in Macaques and Marmosets.Veterinary sciences · 2024Review
- Association of different types of abortions with neonatal outcomes in subsequent pregnancy.Journal of global health · 2024Article
- Aya Contigo: evaluation of a digital intervention to support self-managed medication abortion in Venezuela.Frontiers in global women's health · 2024Article
- Abortion Surveillance - United States, 2021.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2023Article
- Progesterone-mediated reversal of mifepristone-induced pregnancy termination in a rat model: an exploratory investigation.Scientific reports · 2023Article
- "I'm going to be forced to have a baby": A study of COVID-19 abortion experiences on Reddit.Perspectives on sexual and reproductive health · 2023Article
- Health Inequities Among People Who Use Drugs in a Post-The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2023Article
- Intravaginal Isoniazid (INH) and Sublingual Misoprostol Versus Sublingual Misoprostol Alone for First-Trimester Induced Abortion: A Randomized Controlled Trial.Medical journal of the Islamic Republic of Iran · 2023Article
- PAPP-A as a screening tool for assessment of gestational age before medication abortion in an intended-use population.Biomarkers in medicine · 2023Article
- Abortion Surveillance - United States, 2020.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2022Article
- Review
- Safety and effectiveness of self-managed medication abortion provided using online telemedicine in the United States: A population based study.Lancet regional health. Americas · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo describe the efficacy, safety, and acceptability of medical abortion in the late first trimester. STUDY
designWe searched PubMed and Cochrane databases for articles in any language that examined the success of medical abortion at gestational ages (>63 to≤84 days gestation). We sought articles that compared: medical abortion with surgical abortion at this gestational age, combination mifepristone and misoprostol and/or misoprostol alone); different dosages of misoprostol; different routes of misoprostol administration; frequency of dosing; and location of medical abortion (in health care facility vs. outpatient management). Our primary outcome was complete abortion. Data was independently abstracted by two authors, graded for evidence quality, and assessed for risk of bias.
resultsThe search strategy returned 3384 articles, nine of which met inclusion criteria. Medical abortion, as compared with surgical abortion, was effective in the late first trimester (94.6% versus 97.9% complete abortion). A combined regimen of mifepristone and misoprostol was significantly more effective than misoprostol alone (90.4 versus 81.6% complete abortion). Complete abortion rates for all regimens investigated ranged from 78.6% to 94.6%. Success rates were higher with repeat dosing of misoprostol both in combination regimens and alone, and with vaginal compared with oral administration for repeat dosing.
conclusionA limited body of evidence indicates a range of efficacy of medical abortion in the late first trimester and highlights the need for well-designed trials in this gestational age range. IMPLICATIONS: This review highlights the need for research focused on the late first trimester to strengthen the body of evidence. The available evidence is limited but offers reassurance that adverse events are rare for later first trimester abortion. Importantly, new research demonstrates that efficacy remains unchanged in the 10th gestational week regardless of whether the medication is taken in a facility or at a woman's home.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.