ArticlePloS one2018
Sensitivity of nasal airflow variables computed via computational fluid dynamics to the computed tomography segmentation threshold.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
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- Morphometric Analysis of the Maxillary Sinus Using CT-Based Air-Cavity Reconstruction: A Retrospective Study.Journal of clinical medicine · 2026Article
- Automated three-dimensional computed tomography analysis for surgical decisions in congenital nasal pyriform aperture stenosis.Pediatric radiology · 2025Article
- Computational Modeling of Nasal Cavity Aerodynamics: Implications for Surgical Outcomes and Targeted Drug Administration.Ear, nose, & throat journal · 2025Article
- Nasal Airflow Dynamics following LeFort I Advancement in Cleft Nasal Deformities: A Retrospective Preliminary Study.Diagnostics (Basel, Switzerland) · 2024Article
- Effects of Mucosal Decongestion on Nasal Aerodynamics: A Pilot Study.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Comparative Analysis of Micrometer-Sized Particle Deposition in the Olfactory Regions of Adult and Pediatric Nasal Cavities: A Computational Study.Pharmaceutics · 2024Article
- Computational Rhinology: Unraveling Discrepancies between In Silico and In Vivo Nasal Airflow Assessments for Enhanced Clinical Decision Support.Bioengineering (Basel, Switzerland) · 2024Review
- Assessing Nasal Epithelial Dynamics: Impact of the Natural Nasal Cycle on Intranasal Spray Deposition.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Correlation analysis of flow parameters in the olfactory cleft and olfactory function.Scientific reports · 2022Article
- [Application of 3D printed nasal vestibular support in the treatment of anterior nostril stenosis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- Article
- The impact of shape uncertainty on aortic-valve pressure-drop computations.International journal for numerical methods in biomedical engineering · 2021Article
- Analysis of nasal air conditioning in subjects with unilateral cleft lip nasal deformity.Respiratory physiology & neurobiology · 2021Article
- The effect of decongestion on nasal airway patency and airflow.Scientific reports · 2021Article
- Pre-surgery planning tool for estimation of resection volume to improve nasal breathing based on lattice Boltzmann fluid flow simulations.International journal of computer assisted radiology and surgery · 2021Article
- Article
- The effect of airway motion and breathing phase during imaging on CFD simulations of respiratory airflow.Computers in biology and medicine · 2020Article
- Normative ranges of nasal airflow variables in healthy adults.International journal of computer assisted radiology and surgery · 2020Article
- Characterization of upper airway airflow dynamics in young adults with isolated Robin sequence: An exploratory investigation.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational fluid dynamics (CFD) allows quantitative assessment of transport phenomena in the human nasal cavity, including heat exchange, moisture transport, odorant uptake in the olfactory cleft, and regional delivery of pharmaceutical aerosols. The first step when applying CFD to investigate nasal airflow is to create a 3-dimensional reconstruction of the nasal anatomy from computed tomography (CT) scans or magnetic resonance images (MRI). However, a method to identify the exact location of the air-tissue boundary from CT scans or MRI is currently lacking. This introduces some uncertainty in the nasal cavity geometry. The radiodensity threshold for segmentation of the nasal airways has received little attention in the CFD literature. The goal of this study is to quantify how uncertainty in the segmentation threshold impacts CFD simulations of transport phenomena in the human nasal cavity. Three patients with nasal airway obstruction were included in the analysis. Pre-surgery CT scans were obtained after mucosal decongestion with oxymetazoline. For each patient, the nasal anatomy was reconstructed using three different thresholds in Hounsfield units (-800HU, -550HU, and -300HU). Our results demonstrate that some CFD variables (pressure drop, flowrate, airflow resistance) and anatomic variables (airspace cross-sectional area and volume) are strongly dependent on the segmentation threshold, while other CFD variables (intranasal flow distribution, surface area) are less sensitive to the segmentation threshold. These findings suggest that identification of an optimal threshold for segmentation of the nasal airway from CT scans will be important for good agreement between in vivo measurements and patient-specific CFD simulations of transport phenomena in the nasal cavity, particularly for processes sensitive to the transnasal pressure drop. We recommend that future CFD studies should always report the segmentation threshold used to reconstruct the nasal anatomy.
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