Evidence map›Paper›PMID 30444641›Full record

ReviewAnnual review of clinical psychology2019

Biomedical Explanations of Psychopathology and Their Implications for Attitudes and Beliefs About Mental Disorders.

Matthew S Lebowitz, Paul S Appelbaum

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Annual review of clinical psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03998748 (Electrophysiological Correlates of Cognition in Depression), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
82.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03998748 naterminatednot on this map

Electrophysiological Correlates of Cognition in Depression

TypeinterventionalSponsorMclean HospitalRan2019 to 2022Enrolled80ConditionsMajor Depressive DisorderArmsSham Genetic Feedback
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 162 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Matthew S LebowitzCenter for Research on Ethical, Legal, and Social Implications of Psychiatric, Neurologic, and Behavioral Genetics; Department of Psychiatry; Columbia University Medical Center; New York, NY 10032, USA; email: msl2207@cumc.columbia.edu.
Paul S AppelbaumCenter for Research on Ethical, Legal, and Social Implications of Psychiatric, Neurologic, and Behavioral Genetics; Department of Psychiatry; Columbia University Medical Center; New York, NY 10032, USA; email: msl2207@cumc.columbia.edu.
Columbia University Irving Medical Center · US

Funding

Center for Research on the Ethical, Legal and Social Implications of Psychiatric, Neurologic and Behavioral GeneticsP50HG007257 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI APPELBAUM, PAUL STUART · 2013 to 2017
$5.4M
Center for Research on Ethical, Legal & Social Implications of Psychiatric, Neurologic & Behavioral GeneticsRM1HG007257 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI APPELBAUM, PAUL STUART · 2018 to 2021
$4.4M
UNDERSTANDING IMPLICATIONS OF GENETIC ATTRIBUTIONS FOR ADDICTIONR00HG010084 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEBOWITZ, MATTHEW · 2020 to 2022
$747k
Understanding Implications of Genetic Attributions for AddictionK99HG010084 · NHGRI · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI LEBOWITZ, MATTHEW · 2018 to 2019
$336k
NHGRI NIH HHS K99 HG010084NHGRI NIH HHS P50 HG007257NHGRI NIH HHS R00 HG010084NHGRI NIH HHS RM1 HG007257
6 · The paper itself

Abstract

Mental disorders are increasingly conceptualized as biomedical diseases, explained as manifestations of genetic and neurobiological abnormalities. Here, we discuss changes in the dominant explanatory accounts of psychopathology that have occurred over time and the driving forces behind these shifts, lay out some real-world evidence for the increasing ascendancy of biomedical explanations, and provide an overview of the types of attitudes and beliefs that may be affected by them. We examine theoretical and conceptual models that are relevant to understanding how biomedical conceptualizations might affect attitudes and beliefs about mental disorders, and we review some empirical evidence that bears on this question. Finally, we examine possible strategies for combatting potential negative effects of biomedical explanations and discuss important conclusions and directions for future research.

Indexed as

Health Knowledge, Attitudes, PracticeMental DisordersSocial StigmaHumansbiological essentialismcausal reasoningmental disordersstigma

Identifiers

PMID30444641
PMCPMC6506347
OpenAlexW2901310000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.