ArticleLab on a chip2018
High-yield paper-based quantitative blood separation system.
Article in Lab on a chip, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Plasma separation from whole blood on paper-based fluidic devices.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- A passive blood separation sensing platform for point-of-care devices.Npj biosensing · 2025Article
- Trimodal Multiplexed Lateral Flow Test Strips Assisted with a Portable Microfluidic Centrifugation Device.Analytical chemistry · 2024Article
- Sample-to-answer lateral flow assay with integrated plasma separation and NT-proBNP detection.Analytical and bioanalytical chemistry · 2024Article
- Modified polysulfone membrane facilitates rapid separation of plasma from whole blood for an effective anti-SARS-CoV-2-IgM diagnosis.Scientific reports · 2023Article
- Article
- Promise and perils of paper-based point-of-care nucleic acid detection for endemic and pandemic pathogens.Lab on a chip · 2023Review
- Microsampling tools for collecting, processing, and storing blood at the point-of-care.Bioengineering & translational medicine · 2023Review
- Engineering At-Home Dilution and Filtration Methods to Enable Paper-Based Colorimetric Biosensing in Human Blood with Cell-Free Protein Synthesis.Biosensors · 2023Article
- Efficient and Simple Paper-Based Assay for Plasma Separation Using Universal Anti-H Agglutinating Antibody.ACS omega · 2022Article
- Toward Next Generation Lateral Flow Assays: Integration of Nanomaterials.Chemical reviews · 2022Review
- Microfluidic Paper-Based Blood Plasma Separation Device as a Potential Tool for Timely Detection of Protein Biomarkers.Micromachines · 2022Article
- Sustainable Copper Electrochemical Stripping onto a Paper-Based Substrate for Clinical Application.ACS measurement science au · 2022Article
- Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review.Chemical Society reviews · 2022Review
- A review of portable quantitative and semi-quantitative devices for measurement of vitamin A in biological samples.Current research in biotechnology · 2022Review
- High-Performance Passive Plasma Separation on OSTE Pillar Forest.Biosensors · 2021Article
- Development of Immunochromatographic Test Kit for Rapid Detection of Specific IgG4 Antibody in Whole-Blood Samples for Diagnosis of Human Gnathostomiasis.Diagnostics (Basel, Switzerland) · 2021Article
- Nucleic acid sample preparation from whole blood in a paper microfluidic device using isotachophoresis.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021Article
- Highly portable quantitative screening test for prostate-specific antigen at point of care.Current research in biotechnology · 2021Article
- Representative subsampling of sedimenting blood.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Interest in developing paper-based devices for point-of-care diagnostics in resource-limited settings has risen remarkably in recent decades. In this paper, we demonstrate what we refer to as "high yield passive rrythrocyte removal" (HYPER) technology, which utilizes capillary forces in a unique cross-flow filtration for the separation of whole blood with performance comparable to centrifuges. As we will demonstrate, state-of-the-art passive blood separation methods implemented in paper-based systems exhibit rapid blood cell clogging on the filtration media or serum outlet and yield only about 10-30% of the total serum present in the sample. Our innovation results from the inclusion of a differentiation pad, which exploits hydrodynamic effects to reduce the formation of a fouling layer on the blood filtration membrane resulting in more than 60% serum yield with undiluted whole blood as direct input. To demonstrate the effectiveness of the HYPER technology we implement it in a lateral flow system and demonstrate the accurate quantification of vitamin A and iron levels in whole blood samples in 15 minutes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.