ArticleJournal of biomedical optics2018
Depth dependence of coherent hemodynamics in the human head.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Dynamic Windkessel autoregulation for optical hemodynamic imaging: quantifying microcirculation, oxygen diffusion, and vascular autoregulation from low-frequency hemodynamic oscillations.Biomedical optics express · 2026Article
- Advanced Techniques for Liver Fibrosis Detection: Spectral Photoacoustic Imaging and Superpixel Photoacoustic Unmixing Analysis for Collagen Tracking.Sensors (Basel, Switzerland) · 2024Article
- Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy.Neurophotonics · 2023Article
- Exploratory study of a multifrequency EIT-based method for detecting intracranial abnormalities.Frontiers in neurology · 2023Article
- Noninvasive Optical Measurements of Dynamic Cerebral Autoregulation by Inducing Oscillatory Cerebral Hemodynamics.Frontiers in neurology · 2021Article
- Characterizing the Action-Observation Network Through Functional Near-Infrared Spectroscopy: A Review.Frontiers in human neuroscience · 2021Review
- Algorithm for Determination of Thresholds of Significant Coherence in Time-Frequency Analysis.Biomedical signal processing and control · 2020Article
- A Review of Cerebral Hemodynamics During Sleep Using Near-Infrared Spectroscopy.Frontiers in neurology · 2020Review
- Phase dual-slopes in frequency-domain near-infrared spectroscopy for enhanced sensitivity to brain tissue: First applications to human subjects.Journal of biophotonics · 2020Article
- Quantitative measurements of cerebral blood flow with near-infrared spectroscopy.Biomedical optics express · 2019Article
- Article
- Multi-distance frequency-domain optical measurements of coherent cerebral hemodynamics.Photonics · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We report a near-infrared spectroscopy (NIRS) study of coherent hemodynamic oscillations measured on the human forehead at multiple source-detector distances (1 to 4 cm). The physiological source of the coherent hemodynamics is arterial blood pressure oscillations at a frequency of 0.1 Hz, induced by cyclic inflation (to a pressure of 200 mmHg) and deflation of two thigh cuffs wrapped around the subject's thighs. To interpret our results, we use a recently developed hemodynamic model and a phasor representation of the oscillations of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations in the tissue (phasors O, D, and T, respectively). The increase in the phase angle between D and O at larger source-detector separations is assigned to greater flow versus volume contributions and to a stronger blood flow autoregulation in deeper tissue (brain cortex) with respect to superficial tissue (scalp and skull). The relatively constant phase lag of T versus arterial blood pressure oscillations at all source-detector distances was assigned to competing effects from stronger autoregulation and smaller arterial-to-venous contributions in deeper tissue with respect to superficial tissue. We demonstrate the application of a hemodynamic model to interpret coherent hemodynamics measured with NIRS and to assess the different nature of shallow (extracerebral) versus deep (cerebral) tissue hemodynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.