Evidence map›Paper›PMID 30443790›Full record

ArticleClinical rheumatology2019

Sclerostin rather than Dickkopf-1 is associated with mSASSS but not with disease activity score in patients with ankylosing spondylitis.

Wenjia Sun, Lizhen Tian, Lichun Jiang, Songzhao Zhang, Meiju Zhou, Jianing Zhu, Jing Xue

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Bone Involvement in Patients with Spondyloarthropathies.Calcified tissue international · 2022
    Review
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  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjia SunDepartment of Rheumatology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, No.88, Jiefang Road, Hangzhou, 310009, China.
Lizhen TianDepartment of Rheumatology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, No.88, Jiefang Road, Hangzhou, 310009, China.
Lichun JiangDepartment of Rheumatology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, No.88, Jiefang Road, Hangzhou, 310009, China.
Songzhao ZhangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Meiju ZhouDepartment of Rheumatology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, No.88, Jiefang Road, Hangzhou, 310009, China.
Jianing ZhuDepartment of Rheumatology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, No.88, Jiefang Road, Hangzhou, 310009, China.
Jing XueDepartment of Rheumatology, School of Medicine, The Second Affiliated Hospital of Zhejiang University, No.88, Jiefang Road, Hangzhou, 310009, China. jingxue@zju.edu.cn.

Funding

Jinhua Science and Technology Bureau 2015-3-040
6 · The paper itself

Abstract

objectiveTo determine the serum levels of Dickkopf-1 (DKK-1) and sclerostin, as well as their correlations with the structural damage assessed by modified stoke ankylosing spondylitis spine score (mSASSS) and the disease activity evaluated by ankylosing spondylitis disease activity score (ASDAS) in patients with ankylosing spondylitis (AS).

methodsEighty-eight AS patients, 26 rheumatoid arthritis (RA) patients, and 26 age- and gender-matched healthy controls (HC) were collected from rheumatic clinic of the Second Affiliated Hospital of Zhejiang University, School of Medicine, between March 2015 and July 2015. Demographic data, parameters of ASDAS, and image evaluations of spine (i.e., mSASSS) were collected. The serum levels of DKK-1 and sclerostin were measured using commercially available ELISA kits.

resultsBoth DKK-1 and sclerostin were significantly higher in the AS patients than in the controls (1855 ± 84.58 vs. 1406 ± 99.76 pg/ml and 106 ± 6.75 vs. 62.78 ± 6.39 pmol/l, respectively, P < 0.05). The correlation analysis suggested a negative correlation between serum sclerostin and mSASSS (P = 0.019, r

conclusionIn the present study, the expressions of serum DKK-1 and sclerostin were independent of disease activity. Sclerostin was negatively correlated with the mSASSS, which suggests that sclerostin may be a potential marker indicating the spine ossification process in AS. The specific mechanism remains to be investigated.

Indexed as

Adaptor Proteins, Signal TransducingAdultArthritis, RheumatoidBone Morphogenetic ProteinsFemaleGenetic MarkersHumansIntercellular Signaling Peptides and ProteinsMaleMiddle AgedSeverity of Illness IndexSpineSpondylitis, AnkylosingYoung AdultAdaptor Proteins, Signal TransducingBone Morphogenetic ProteinsDKK1 protein, humanGenetic MarkersIntercellular Signaling Peptides and ProteinsSOST protein, humanAnkylosing spondylitisAS disease activity score (ASDAS)Dickkopf-1 (DKK-1)Modified stoke ankylosing spondylitis spine score (mSASSS)Sclerostin

Identifiers

PMID30443790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.