ArticleChemistry Central journal2018
Green multicomponent synthesis, antimicrobial and antioxidant evaluation of novel 5-amino-isoxazole-4-carbonitriles.
Article in Chemistry Central journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Innovative hafnium composite: efficient fabrication and advanced biomedical potential in dentistry and oral health.RSC advances · 2025Article
- Article
- Loading of green-synthesized cu nanoparticles on Ag complex containing 1,3,5-triazine Schiff base with enhanced antimicrobial activities.Scientific reports · 2023Article
- Methanol extract of Iraqi Kurdistan RegionFrontiers in chemistry · 2023Article
- Synthesis of some new isoxazole compounds and their biological tyrosinase and antioxidant activities.Turkish journal of chemistry · 2022Article
- Synthesis of efficient cobalt-metal organic framework as reusable nanocatalyst in the synthesis of new 1,4-dihydropyridine derivatives with antioxidant activity.Frontiers in chemistry · 2022Article
- In vitro and molecular docking and analysis of isoxazoline derivatives with DPPH.Bioinformation · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundDesign and synthesis of new inhibitor agents to deal with pathogenic microorganisms is expanding. In this project, an efficient, environmentally friendly, economical, rapid and mild procedure was developed for the synthesis of novel functionalized isoxazole derivatives as antimicrobial potentials.
methodsMulticomponent reaction between malononitrile (1), hydroxylamine hydrochloride (2) and different aryl or heteroaryl aldehydes 3a-i afforded novel 5-amino-isoxazole-4-carbonitriles 4a-i in good product yields and short reaction times. Deep eutectic solvent K
resultsBroad-spectrum antimicrobial activities were observed with isoxazoles 4a, b, d. In addition, antioxidant activity of isoxazole 4i was proven on DPPH.
conclusionsIn this project, compounds 4a, b, d could efficiently inhibit the growth of various bacterial and fungal pathogens. Antioxidant properties of derivative 4i were also significant. These biologically active compounds are suitable candidates to synthesize new prodrugs and drugs due to the presence of different functional groups on their rings.
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