Evidence map›Paper›PMID 30443663›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode.

Jessica Scharrenbroich, Volkhard Kaever, Stefan Dove, Roland Seifert, Erich H Schneider

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. cUMP elicits interendothelial gap formation duringAmerican journal of physiology. Lung cellular and molecular physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jessica ScharrenbroichHannover Medical School, Institute of Pharmacology, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Volkhard KaeverResearch Core Unit Metabolomics, Hannover Medical School, Institute of Pharmacology, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Stefan DoveDepartment of Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, 93040, Regensburg, Germany.
Roland SeifertHannover Medical School, Institute of Pharmacology, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Erich H SchneiderHannover Medical School, Institute of Pharmacology, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. schneider.erich@mh-hannover.de.ORCID http://orcid.org/0000-0002-7905-4276
Medizinische Hochschule Hannover · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The non-canonical cyclic nucleotide cUMP and the phosphodiesterase PDE9A both occur in neuronal cells. Using HPLC-coupled tandem mass spectrometry, we characterized the kinetics of PDE9A-mediated cUMP hydrolysis. PDE9A is a low-affinity and high-velocity enzyme for cUMP (V

Indexed as

3',5'-Cyclic-AMP PhosphodiesterasesHumansHydrolysisKineticsMolecular Docking SimulationNucleotides, CyclicProtein BindingPyrazolesPyrimidinesRecombinant ProteinsUridine Monophosphate3',5'-Cyclic-AMP PhosphodiesterasesBAY 73-6691cyclic 3',5'-uridine monophosphateNucleotides, CyclicPDE9A protein, humanPyrazolesPyrimidinesRecombinant ProteinsUridine MonophosphateCyclic CMPCyclic UMPEnzyme kineticsGlutamine switchPDE9APhosphodiesterase

Identifiers

PMID30443663
OpenAlexW2901404219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.