ArticleScience advances2018
Impact of modular organization on dynamical richness in cortical networks.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Ethics and Regulation of Human Brain Organoid Research: Recommendations from the Asia Pacific Neuroethics Working Group.Asian bioethics review · 2026Article
- Modular nest structure influences activity cycle synchronisation in ant colonies.Communications biology · 2026Article
- Microfluidic platforms for probing spontaneous functional recovery in hierarchically modular neuronal networks.Communications engineering · 2026Article
- Article
- Multi-organoid loop cerebral connectoids exhibit enhanced neuronal network dynamics and sequence-specific entrainment.Communications biology · 2026Article
- Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling.ACS nano · 2025Article
- Role of connectivity anisotropies in the dynamics of cultured neuronal networks.PLoS computational biology · 2025Article
- Microtube-integrated chips for modular electrical stimulation and 3D confined neural network growth.Microsystems & nanoengineering · 2025Article
- Harnessing Intelligence from Brain Cells In Vitro.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Modular architecture confers robustness to damage and facilitates recovery in spiking neural networks modelingFrontiers in neuroscience · 2025Article
- Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024Article
- Reverse engineering of feedforward cortical-Hippocampal microcircuits for modelling neural network function and dysfunction.Scientific reports · 2024Article
- The Profile of Network Spontaneous Activity and Functional Organization Interplay in Hierarchically Connected Modular Neural Networks In Vitro.Micromachines · 2024Article
- Preparation and Mechano-Functional Characterization of PEGylated Fibrin Hydrogels: Impact of Thrombin Concentration.Gels (Basel, Switzerland) · 2024Article
- Breaking reflection symmetry: evolving long dynamical cycles in Boolean systems.New journal of physics · 2024Article
- Investigating the interplay between segregation and integration in developing cortical assemblies.Frontiers in cellular neuroscience · 2024Article
- Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry.Communications biology · 2023Article
- Connectivity and network burst properties of in-vitro neuronal networks induced by a clustered structure with alginate hydrogel patterning.Biomedical engineering letters · 2023Article
- Multiple neuron clusters on Micro-Electrode Arrays as an in vitro model of brain network.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As in many naturally formed networks, the brain exhibits an inherent modular architecture that is the basis of its rich operability, robustness, and integration-segregation capacity. However, the mechanisms that allow spatially segregated neuronal assemblies to swiftly change from localized to global activity remain unclear. Here, we integrate microfabrication technology with in vitro cortical networks to investigate the dynamical repertoire and functional traits of four interconnected neuronal modules. We show that the coupling among modules is central. The highest dynamical richness of the network emerges at a critical connectivity at the verge of physical disconnection. Stronger coupling leads to a persistently coherent activity among the modules, while weaker coupling precipitates the activity to be localized solely within the modules. An in silico modeling of the experiments reveals that the advent of coherence is mediated by a trade-off between connectivity and subquorum firing, a mechanism flexible enough to allow for the coexistence of both segregated and integrated activities. Our results unveil a new functional advantage of modular organization in complex networks of nonlinear units.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.