ReviewCureus2018
Pain Management in Metastatic Bone Disease: A Literature Review.
Review in Cureus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04808531 (NanaBis™ an Oro-buccal Administered Equimolar d9-THC & CBD Formulation as Monotherapy for Management of Opioid Requiring Bone Pain Due to Metastatic Cancer), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NanaBis™ an Oro-buccal Administered Equimolar d9-THC & CBD Formulation as Monotherapy for Management of Opioid Requiring Bone Pain Due to Metastatic Cancer: Phase 3 Multi Centre Blinded Randomized Withdrawal Active & Placebo Controlled Trial
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cryoablation for the Palliation of Painful Bone Metastasis: A Systematic Review.Cardiovascular and interventional radiology · 2023Pooled it
- MDA-9/Syntenin small molecule inhibitor IVMT-Rx-4 blocks prostate cancer bone metastasis.Pharmacological research · 2026Article
- Chinese acupoint therapies in cancer pain management: research advances and future perspectives.Pain management · 2025Review
- Article
- Single-Cell Transcriptome Analyses of Four Pain Related Genes in Osteosarcoma.Cancer informatics · 2025Article
- Case Report: A case of femoral metastatic cancer misdiagnosed as isolated femoral lesser trochanter avulsion fracture.Frontiers in oncology · 2025Article
- Complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors: WFNS spine committee recommendations.Neurosurgical review · 2024Review
- HAS THE AGING OF BRAZILIANS IMPACTED THE OCCURRENCE OF OSTEO-CARTILAGINOUS NEOPLASMS?Acta ortopedica brasileira · 2024Article
- Breakthrough pain and rapid-onset opioids in patients with cancer pain: a narrative review.Journal of Yeungnam medical science · 2024Article
- Review
- The Edmonton Classification System for Cancer Pain in Patients with Bone Metastasis: a descriptive cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Pharmacological Efficacy of Repurposing Drugs in the Treatment of Prostate Cancer.International journal of molecular sciences · 2023Review
- Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications.Frontiers in molecular neuroscience · 2023Review
- Analysis of Various Factors Associated With Opioid Dose Escalation in Patients With Cancer Pain.Cureus · 2022Article
- Targeting the Wnt signaling pathway for breast cancer bone metastasis therapy.Journal of molecular medicine (Berlin, Germany) · 2022Review
- An Overview of Decision Making in the Management of Metastatic Spinal Tumors.Indian journal of orthopaedics · 2021Review
- Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Article
- Phosphoproteomic Profiling of Rat's Dorsal Root Ganglia Reveals mTOR as a Potential Target in Bone Cancer Pain and Electro-Acupuncture's Analgesia.Frontiers in pharmacology · 2021Article
- Spinal Cord Stimulation as Treatment for Cancer and Chemotherapy-Induced Pain.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
- Management of cancer pain with analgetic adjuvant and weak opioid in prostate cancer bone metastases: A case series.Annals of medicine and surgery (2012) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer means an uncontrolled division of abnormal cells in the body. It is a leading cause of death today. Not only the disease itself but its complications are also adding to the increase in mortality rate. One of the major complications is the pain due to metastasis of cancer. Pain is a complex symptom which has physical, psychological, and emotional impacts that influence the daily activities as well as social life. Pain acts as an alarm sign, telling the body that something is wrong. Pain can manifest in a multitude fashion. Management of bone pain due to metastasis involves different modes with some specific treatments according to the type of primary cancer. Over the years various treatment modalities have been tried and tested to improve the pain management including the use of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, bisphosphonates, tricyclic antidepressants, corticosteroids, growth factors and signaling molecules, ET-1 receptor antagonists, radiotherapy as well as surgical management. The topic of discussion will cover each one of these in detail.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.