Evidence map›Paper›PMID 30443332›Full record

ReviewInterface focus2018

Something has to give: scaling combinatorial computing by biological agents exploring physical networks encoding NP-complete problems.

Falco C M J M van Delft, Giulia Ipolitti, Dan V Nicolau, Ayyappasamy Sudalaiyadum Perumal, Ondřej Kašpar, Sara Kheireddine, Sebastian Wachsmann-Hogiu, Dan V Nicolau

Erratum issuedOpen access · hybridAbstract readReview
In one paragraph

Review in Interface focus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Why cellular computations challenge our design principles.Seminars in cell & developmental biology · 2025
    Review
  3. Engineering signalling pathways in mammalian cells.Nature biomedical engineering · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Patterns of bacterial motility in microfluidics-confining environments.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Falco C M J M van DelftMolecular Sense Ltd, Liverpool L36 8HT, UK.ORCID 0000-0002-3234-2211
Giulia IpolittiDepartment of Bioengineering, McGill University, Montreal, Quebec, Canada H3A 0E9.ORCID 0000-0001-9339-304X
Dan V NicolauMolecular Sense Ltd, Liverpool L36 8HT, UK.ORCID 0000-0002-7758-226X
Ayyappasamy Sudalaiyadum PerumalDepartment of Bioengineering, McGill University, Montreal, Quebec, Canada H3A 0E9.ORCID 0000-0002-1360-9152
Ondřej KašparDepartment of Bioengineering, McGill University, Montreal, Quebec, Canada H3A 0E9.ORCID 0000-0001-5353-6069
Sara KheireddineDepartment of Bioengineering, McGill University, Montreal, Quebec, Canada H3A 0E9.ORCID 0000-0002-1755-200X
Sebastian Wachsmann-HogiuDepartment of Bioengineering, McGill University, Montreal, Quebec, Canada H3A 0E9.ORCID 0000-0002-3761-3834
Dan V NicolauDepartment of Bioengineering, McGill University, Montreal, Quebec, Canada H3A 0E9.ORCID 0000-0002-9956-0600
McGill University · CAQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

On-chip network-based computation, using biological agents, is a new hardware-embedded approach which attempts to find solutions to combinatorial problems, in principle, in a shorter time than the fast, but sequential electronic computers. This analytical review starts by describing the underlying mathematical principles, presents several types of combinatorial (including NP-complete) problems and shows current implementations of proof of principle developments. Taking the subset sum problem as example for in-depth analysis, the review presents various options of computing agents, and compares several possible operation 'run modes' of network-based computer systems. Given the brute force approach of network-based systems for solving a problem of input size C, 2

Indexed as

bio-computationcombinatorial problemshardware-embedded solutionsnetwork-based computationNP-complete problemssubset sum problem

Identifiers

PMID30443332
PMCPMC6227808
OpenAlexW2898030281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.