Evidence map›Paper›PMID 30443250›Full record

ArticleFrontiers in immunology2018

Clinical, Immunological, and Molecular Heterogeneity of 173 Patients With the Phenotype of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome.

Eleonora Gambineri, Sara Ciullini Mannurita, David Hagin, Marina Vignoli, Stephanie Anover-Sombke, Stacey DeBoer, Gesmar R S Segundo, Eric J Allenspach, Claudio Favre, Hans D Ochs and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05241444 (Phase 1 Study of Autologous CD4^LVFOXP3 in Participants With Immune Dysregulation Polyendocrinopathy Enteropathy X-linked), which is not on this map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05241444 phase1recruitingnot on this mapstarted 2022, after this paper: background citation

Phase 1 Study of Autologous CD4^LVFOXP3 in Participants With Immune Dysregulation Polyendocrinopathy Enteropathy X-linked (IPEX) Syndrome

TypeinterventionalSponsorBacchetta, Rosa, MDRan2022 to 2037Enrolled30ConditionsIPEXArmsCD4^LVFOXP3
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 182 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Inborn errors of regulatory T-cell differentiation and function.The Journal of allergy and clinical immunology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Monogenic inflammatory bowel disease: An unfolding enigma.World journal of clinical pediatrics · 2025
    Review
  11. Review
  12. Genes · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Cellular and molecular basis of proximal small intestine disorders.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  18. Article
  19. Review
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Eleonora GambineriDepartment of NEUROFARBA, University of Florence, Florence, Italy.
Sara Ciullini MannuritaDepartment of NEUROFARBA, University of Florence, Florence, Italy.
David HaginSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
Marina VignoliDepartment of NEUROFARBA, University of Florence, Florence, Italy.
Stephanie Anover-SombkeSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
Stacey DeBoerSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
Gesmar R S SegundoSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
Eric J AllenspachSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
Claudio FavreOncology/Hematology Department, "Anna Meyer" Children's Hospital, Florence, Italy.
Hans D OchsSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
Troy R TorgersonSeattle Children's Research Institute, University of Washington, Seattle, WA, United States.
University of Washington · USSeattle Children's Hospital · USMeyer Children's Hospital · ITUniversity of Florence · IT

Funding

FOXP3 Structure, Function and Regulatory Activity in T cellsK08AI063267 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI TORGERSON, TROY R · 2007 to 2009
$407k
NIAID NIH HHS K08 AI063267
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genes, X-LinkedGenetic Association StudiesGenetic Predisposition to DiseasePhenotypeAdolescentAdultAmino Acid SequenceAmino Acid SubstitutionBiomarkersChildChild, PreschoolDNA Mutational AnalysisFemaleFlow CytometryForkhead Transcription FactorsGenetic HeterogeneityBiomarkersForkhead Transcription FactorsFOXP3 protein, humanImmunoglobulin EenteropathyFOXP3immune dysregulationimmune regulatory genesIPEX-likepolyendocrinopathyregulatory T cellsX-linked (IPEX)

Identifiers

PMID30443250
PMCPMC6223101
OpenAlexW2898668831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.