Evidence map›Paper›PMID 30443043›Full record

ReviewNature reviews. Endocrinology2018

The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.

Fadil M Hannan, Enikö Kallay, Wenhan Chang, Maria Luisa Brandi, Rajesh V Thakker

Open access · greenAbstract readComparative StudyReview
In one paragraph

Review in Nature reviews. Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 4 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 4 syntheses or guidelines pooled it, 363 citations in OpenAlex.

  1. The calcium-sensing receptor in sepsis and septic shock, mechanistic pathways and translational perspectives: a systematic review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Pooled it
  2. Pooled it
  3. Autosomal Dominant Hypocalcemia Type 1: A Systematic Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Pooled it
  4. Pooled it
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141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Fadil M HannanDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Enikö KallayDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Wenhan ChangEndocrine Research Unit, Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6583-7176
Maria Luisa BrandiMetabolic Bone Diseases Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy. marialuisa.brandi@unifi.it.
Rajesh V ThakkerAcademic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. rajesh.thakker@ndm.ox.ac.uk.ORCID http://orcid.org/0000-0002-1438-3220
Medical University of Vienna · ATSan Francisco VA Medical Center · USUniversity of Florence · ITUniversity of Liverpool · GBUniversity of Oxford · GB

Funding

UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
Regulation of Parathyroid Functions By G-Protein Coupled ReceptorsR01DK122259 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN, VILARDAGA, JEAN-PIERRE · 2019 to 2023
$2.2M
Regulation of PTH secretion by TRPC1R01DK121656 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CHANG, WENHAN, TSIOKAS, LEONIDAS · 2019 to 2022
$2.1M
Combined PTH and Calcimimetic Therapy and Its Mechanisms for OsteoanabolismR01AR067291 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN · 2015 to 2019
$1.7M
A novel treatment for bone fracture repairI01BX003453 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI CHANG, WENHAN · 2018 to 2021
–
Austrian Science Fund FWF P 29948BLRD VA I01 BX003453Medical Research Council G0601423Medical Research Council G1000467Medical Research Council G9825289NIAMS NIH HHS P30 AR066262NIAMS NIH HHS R01 AR067291NIDDK NIH HHS R01 DK121656NIDDK NIH HHS R01 DK122259Wellcome Trust 106995
6 · The paper itself

Abstract

The Ca

Indexed as

Calcimimetic AgentsFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansHypercalcemiaHypercalciuriaHypocalcemiaHypoparathyroidismIncidenceMaleMutationNephrolithiasisPrognosisReceptors, Calcium-SensingRisk AssessmentCalcimimetic AgentsReceptors, Calcium-Sensing

Identifiers

PMID30443043
PMCPMC6535143
OpenAlexW2901644191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.