ArticleHypertension research : official journal of the Japanese Society of Hypertension2019
Treatment patterns and adherence to antihypertensive combination therapies in Japan using a claims database.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis.International journal of clinical pharmacy · 2021Pooled it
- Esaxerenone versus angiotensin II receptor blockers as second-line therapy in older Japanese patients with uncontrolled hypertension on calcium channel blockers: the randomized, open-label ESCORT-HT study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Trial
- Blood pressure status, JSH 2019-based control rate, and associated factors among community-dwelling adults: The NOSE study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Sociodemographic factors associated with medication adherence among hypertensive patients in northern Peru: a cross-sectional study.Archivos de cardiologia de Mexico · 2025Article
- Persistence and adherence to levodopa adjunct medications in elderly patients with Parkinson's disease: a retrospective cohort study using a Japanese claims database.Frontiers in neurology · 2025Article
- Review
- The impact of clinical inertia on uncontrolled blood pressure in treated hypertension: real-world, longitudinal data from Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Relationships Between Arterial Pressure-Volume Index and Cardiovascular Disease Biomarkers in Patients With Hypertension.Journal of clinical medicine research · 2022Article
- Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations.Molecular pharmaceutics · 2021Article
- Improving patient adherence: the last obstacle to achieving hypertension control.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Mass clinical survey as a possible population strategy for the better control of hypertension in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Comprehensive Trends and Patterns of Antihypertensive Prescriptions Using a Nationwide Claims Database in Korea.Clinical epidemiology · 2020Article
- Treatment patterns of antihypertensive fixed-dose combinations according to age and number of agents prescribed: Retrospective analysis using a Japanese claims database.Geriatrics & gerontology international · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fixed-dose combinations (FDCs) for blood pressure control can simplify prescribing, improve medication adherence, and be cost-effective. In Japan, real-world data about the class effects of antihypertensive drugs on medication adherence are limited. Using the nationwide database of medical health claims from Diagnosis Procedure Combination hospitals, treatment patterns and adherence were analyzed for 47,891 patients prescribed antihypertensive medication between April 2014 and March 2015. Adherence was assessed by the proportion of days covered (expressed as % PDC). Patients were prescribed a mean of 2.0 ± 1.0 antihypertensive drugs and 2.4 ± 1.7 pills for their index prescription. Mean adherence overall was 91.5% PDC and was inversely correlated with the number of antihypertensive drugs or pills prescribed on the index date. Mean % PDC was significantly higher (all P < 0.0001) for CCB + ARB versus ARB + thiazide diuretic combinations and for CCB + ARB + β-blocker versus CCB + ARB + thiazide diuretic combinations. Adherence was significantly higher (P < 0.0001) for FDC (CCB + ARB) versus corresponding single-drug combinations, but not for other comparisons of FDCs versus single-drug combinations. On the other hand, FDCs were not always used effectively; specifically, FDCs were frequently used concomitantly with a single agent(s) from the same drug class(es) as the FDC. From the results of our study, no clear differences were observed in medication adherence according to the presence or absence of FDC formulations, and there were cases in which FDCs were not being utilized effectively to simplify prescribing.
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