ArticleScientific reports2018
The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Morphological correlates of synaptic protein turnover in the mouse brain.Life science alliance · 2024Article
- Determining and interpreting protein lifetimes in mammalian tissues.Trends in biochemical sciences · 2023Review
- Toxicokinetics and metabolism of deoxynivalenol in animals and humans.Archives of toxicology · 2022Review
- A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines.Nature neuroscience · 2021Article
- Article
- Translational control in aging and neurodegeneration.Wiley interdisciplinary reviews. RNA · 2021Review
- Review
- Global and Site-Specific Effect of Phosphorylation on Protein Turnover.Developmental cell · 2021Article
- A Standardized Brain Molecular Atlas: A Resource for Systems Modeling and Simulation.Frontiers in molecular neuroscience · 2021Article
- In Vivo Protein Lifetime Measurements Across Multiple Organs in the Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Proteome Turnover in the Spotlight: Approaches, Applications, and Perspectives.Molecular & cellular proteomics : MCP · 2021Review
- A comparative analysis of the mobility of 45 proteins in the synaptic bouton.The EMBO journal · 2020Article
- A mass spectrometry workflow for measuring protein turnover rates in vivo.Nature protocols · 2019Article
- Pathological changes are associated with shifts in the employment of synonymous codons at the transcriptome level.BMC genomics · 2019Article
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Authors and funding
21 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homeostasis of the proteome depends on the tight regulation of the mRNA and protein abundances, of the translation rates, and of the protein lifetimes. Results from several studies on prokaryotes or eukaryotic cell cultures have suggested that protein homeostasis is connected to, and perhaps regulated by, the protein and the codon sequences. However, this has been little investigated for mammals in vivo. Moreover, the link between the coding sequences and one critical parameter, the protein lifetime, has remained largely unexplored, both in vivo and in vitro. We tested this in the mouse brain, and found that the percentages of amino acids and codons in the sequences could predict all of the homeostasis parameters with a precision approaching experimental measurements. A key predictive element was the wobble nucleotide. G-/C-ending codons correlated with higher protein lifetimes, protein abundances, mRNA abundances and translation rates than A-/U-ending codons. Modifying the proportions of G-/C-ending codons could tune these parameters in cell cultures, in a proof-of-principle experiment. We suggest that the coding sequences are strongly linked to protein homeostasis in vivo, albeit it still remains to be determined whether this relation is causal in nature.
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