Evidence map›Paper›PMID 30442915›Full record

ArticleScientific reports2018

Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.

Katrin Vogel, Mandy Pierau, Aditya Arra, Karen Lampe, Dirk Schlueter, Christoph Arens, Monika C Brunner-Weinzierl

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. The accuracy of the Candida ScoreAnnals of medicine · 2025
    Article
  2. Frequency of synaptic antigen-specific CD4Immunity & ageing : I & A · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katrin VogelDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.
Mandy PierauDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.
Aditya ArraDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.
Karen LampeDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.
Dirk SchlueterInstitute of Medical Microbiology and Hygiene, Otto-von-Guericke-University, Magdeburg, Germany.
Christoph ArensDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.
Monika C Brunner-WeinzierlDepartment of Experimental Paediatrics, University Hospital, Otto-von-Guericke University, Magdeburg, Germany. Monika.Brunner-Weinzierl@med.ovgu.de.
Otto-von-Guericke University Magdeburg · DEInstitute of Medical Microbiology and Hygiene · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The origin of human T-cell responses against fungal pathogens early in life is not clearly understood. Here, we show that antifungal T-cell responses are vigorously initiated within the first years of life against lysates and peptides of Candida albicans or Aspergillus fumigatus, presented by autologous monocytes. The neonatal responding T-cell pool consists of 20 different TCR-V

Indexed as

Age FactorsAspergillus fumigatusBiomarkersCandida albicansCell DifferentiationCell ProliferationChildChild, PreschoolGrowth and DevelopmentHumansInfantInfant, NewbornInterleukin-17Interleukin-4Lymphocyte ActivationTh1 CellsBiomarkersInterleukin-17Interleukin-4

Identifiers

PMID30442915
PMCPMC6238003
OpenAlexW2899820782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.