Evidence map›Paper›PMID 30442878›Full record

ArticleAging2018

Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in

Le Li, Yi Chen, Changchi Chenzhao, Shuxiang Fu, Qumiao Xu, Jinfeng Zhao

Abstract read
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. International journal of molecular sciences · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Le Li *Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China.
Yi Chen *Department of Laboratory Medicine, Xiangya Medical School, Central South University, Changsh, Changsha 410013, China.
Changchi ChenzhaoXinxiang Medical University, Hongqi District, 453003 Xinxiang, China.
Shuxiang FuForevertek Biotechnology Co.,Ltd, Building M0, Oversea Graduate Park National High-tech Industrial Zone, Changsha 10003, China.
Qumiao XuBGI-Shenzhen, BeiShan Industrial Zone, Yantian District, Shenzhen, Guangdong 518083, China.
Jinfeng ZhaoKey Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High glucose levels negatively affect immune response. However, the underlying mechanisms are not well understood. Upon infection, the round worm

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsGene Expression RegulationGlucoseHost-Pathogen InteractionsImmunity, InnateNF-E2-Related Factor 2Salmonella typhimuriumTranscription FactorsCaenorhabditis elegans ProteinsDNA-Binding ProteinsGlucoseNF-E2-Related Factor 2skn-1 protein, C elegansTranscription Factorsagingglucose metabolismhyperglycemiainnate immunityNrf2

Identifiers

PMID30442878
PMCPMC6286829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.