Evidence map›Paper›PMID 30442812›Full record

ArticleClinical science (London, England : 1979)2018

Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction.

Vidya K Nagalakshmi, Minghong Li, Soham Shah, Joseph C Gigliotti, Alexander L Klibanov, Frederick H Epstein, Robert L Chevalier, R Ariel Gomez, Maria Luisa S Sequeira-Lopez

Open access · greenAbstract read
In one paragraph

Article in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Acute kidney injury in urological conditions.Asian biomedicine : research, reviews and news · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Expression ofAmerican journal of physiology. Renal physiology · 2020
    Article
  9. Article
  10. Article
  11. Acute Kidney Injury Caused by Obstructive Nephropathy.International journal of nephrology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Vidya K NagalakshmiDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Minghong LiDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Soham ShahDepartment of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA, U.S.A.
Joseph C GigliottiDepartment of Integrated Physiology and Pharmacology, Liberty University College of Osteopathic Medicine, Lynchburg, VA, U.S.A.
Alexander L KlibanovCardiovascular Division, University of Virginia Health System, VA, U.S.A.
Frederick H EpsteinDepartment of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA, U.S.A.
Robert L ChevalierDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
R Ariel GomezDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Maria Luisa S Sequeira-LopezDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A. msl7u@virginia.edu.ORCID 0000-0002-4459-7940
University of Virginia · USUniversity of Virginia Health System · USLiberty University · US

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
MRI of Myocardial Function in Post-Infarct Knockout MiceR01EB001763 · NIBIB · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI EPSTEIN, FREDERICK H · 2003 to 2020
$5.4M
Development of the Renal ArteriolesR01DK091330 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2011 to 2015
$1.7M
Fate of the kidney vasculature during partial neonatal ureteral obstructionR01DK116196 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2018 to 2021
$1.5M
NIBIB NIH HHS R01 EB001763NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK091330NIDDK NIH HHS R01 DK116196
6 · The paper itself

Abstract

Congenital obstructive nephropathy is a major cause of chronic kidney disease (CKD) in children. The contribution of changes in the identity of renal cells to the pathology of obstructive nephropathy is poorly understood. Using a partial unilateral ureteral obstruction (pUUO) model in genetically modified neonatal mice, we traced the fate of cells derived from the renal stroma, cap mesenchyme, ureteric bud (UB) epithelium, and podocytes using

Indexed as

Cell DifferentiationCell LineageCell ProliferationRegenerationAnimalsAnimals, NewbornCell TrackingDisease Models, AnimalFibrosisGene Expression Regulation, DevelopmentalHomeodomain ProteinsHydronephrosisKidneyMice, TransgenicNeovascularization, PhysiologicOxidative StressHomeodomain ProteinsHoxb7 protein, mouseSix2 protein, mouseTranscription Factorskidney regenerationlineage tracingnephrovascular developmentobstructive nephropathyrenal progenitors

Identifiers

PMID30442812
PMCPMC6415776
OpenAlexW2901489970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.