Evidence map›Paper›PMID 30442809›Full record

ArticleScience (New York, N.Y.)2018

Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry.

Dror S Chorev, Lindsay A Baker, Di Wu, Victoria Beilsten-Edmands, Sarah L Rouse, Tzviya Zeev-Ben-Mordehai, Chimari Jiko, Firdaus Samsudin, Christoph Gerle, Syma Khalid and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 195 citations in OpenAlex.

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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Dror S ChorevPhysical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.ORCID 0000-0002-0751-0092
Lindsay A BakerDivision of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0001-9578-4263
Di WuPhysical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.
Victoria Beilsten-EdmandsPhysical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.
Sarah L RouseDepartment of Life Sciences, Imperial College, London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0002-7115-1565
Tzviya Zeev-Ben-MordehaiDivision of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. carol.robinson@chem.ox.ac.uk.ORCID 0000-0002-2571-550X
Chimari JikoInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Kumatori, Japan.
Firdaus SamsudinSchool of Chemistry, University of Southampton, University Road, Southampton SO17 1BJ, UK.ORCID 0000-0003-2766-4459
Christoph GerleInstitute for Protein Research, Osaka University, Suita, Osaka, Japan.ORCID 0000-0002-7265-2804
Syma KhalidSchool of Chemistry, University of Southampton, University Road, Southampton SO17 1BJ, UK.
Alastair G StewartMolecular, Structural and Computational Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.ORCID 0000-0002-2070-6030
Stephen J MatthewsDepartment of Life Sciences, Imperial College, London, South Kensington Campus, London SW7 2AZ, UK.ORCID 0000-0003-0676-0927
Kay GrünewaldDivision of Structural Biology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.ORCID 0000-0002-4788-2691
Carol V RobinsonPhysical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK. carol.robinson@chem.ox.ac.uk.ORCID 0000-0001-7829-5505
University of Oxford · GBImperial College London · GBUniversity of Southampton · GBJapan Science and Technology Agency · JPKyoto University · JPUniversität Hamburg · DEVictor Chang Cardiac Research Institute · AU

Funding

European Research Council 695511Medical Research Council MR/M019292/1Medical Research Council MR/P028225/1Wellcome Trust 104633
6 · The paper itself

Abstract

Membrane proteins reside in lipid bilayers and are typically extracted from this environment for study, which often compromises their integrity. In this work, we ejected intact assemblies from membranes, without chemical disruption, and used mass spectrometry to define their composition. From

Indexed as

Adenine Nucleotide Translocator 1AnimalsBacterial Outer Membrane ProteinsBacterial ProteinsCattleEscherichia coli ProteinsLipid BilayersMass SpectrometryMembrane ProteinsMitochondrial MembranesMitochondrial Proton-Translocating ATPasesMolecular ChaperonesPorinsProtein Conformation, beta-StrandProteomeSEC Translocation ChannelsAdenine Nucleotide Translocator 1Bacterial Outer Membrane ProteinsBacterial ProteinsEscherichia coli ProteinsF1F0-ATP synthaseLipid BilayersMembrane ProteinsMitochondrial Proton-Translocating ATPasesMolecular ChaperonesPorinsProteomeSEC Translocation ChannelstonB protein, Bacteria

Identifiers

PMID30442809
PMCPMC6522346
OpenAlexW2901712030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.