ArticleScience (New York, N.Y.)2018
LZTR1 is a regulator of RAS ubiquitination and signaling.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.
0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
145 citing papers in PubMed, 226 citations in OpenAlex.
- Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration.iScience · 2026Article
- Targeting Interleukin-8-Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome.Circulation · 2026Article
- Landscape of Somatic Mutations in a Large Cohort of Chinese Patients With Immune Dysregulations.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Multifaceted roles of KCTD17 in cellular homeostasis and disease.BMB reports · 2026Review
- Article
- Evolution of KRAS molecular glues: from allele-selective to Pan-RAS and protein-protein interaction modulators.Acta pharmacologica Sinica · 2026Review
- Malignant transformation of a testosterone-secreting ovarian steroid cell tumor: a case report.Gynecologic oncology reports · 2026Article
- GCN5-ERK lactylation-phosphorylation loop amplifies lactate-driven cancer progression.Nature chemical biology · 2026Article
- Cullin 3 substrate-adaptor protein 1 (MtCSP1) modulates nodulation through interaction with the GTPase ARFA1.Scientific reports · 2026Article
- LZTR1 Loss Reduces Vimentin Expression and Motility in Hep3B Hepatocellular Carcinoma Cells.International journal of molecular sciences · 2026Article
- Evaluating the Genetic Overlap Between Congenital Heart Disease and Neuroblastoma Risk.Pediatric blood & cancer · 2026Article
- Tumor suppressor genes and KRAS G12C inhibitor resistance in non-small cell lung cancer.iScience · 2026Review
- Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation.bioRxiv : the preprint server for biology · 2026Article
- USP10-mediated deubiquitination and activation ofActa pharmaceutica Sinica. B · 2026Article
- Central nervous system schwannoma, VGLL-fused (EWSR1::VGLL1 fusion) with neuroblastoma-like cell dense areas in the frontal lobe of a young man with schwannomatosis due to a germline LZTR1 mutation.Free neuropathology · 2026Article
- Circular RNA Hsa_circ_0062403 Acts as a Potential Prognostic Biomarker for Early Recurrence of Hepatocellular Carcinoma.International journal of general medicine · 2026Article
- Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation.Nature communications · 2025Article
- Molecular pathogenesis of the schwannomatosis genes and genetic testing strategies.Familial cancer · 2025Review
- LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8Cell discovery · 2025Article
- Article
85 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byRas tuning.2019
Authors and funding
18 authors at 3 institutions in 3 countries.
Johannes W BigenzahnCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0002-5214-4570
Giovanna M ColluDepartment of Cell, Developmental, and Regenerative Biology and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.ORCID 0000-0002-7437-4000
Felix KartnigCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0001-8540-2831
Melanie PieraksCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Gregory I VladimerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0003-4205-7585
Leonhard X HeinzCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0002-6921-1493
Vitaly SedlyarovCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0002-9872-3535
Fiorella SchischlikCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Astrid FausterCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0003-4608-5604
Manuele RebsamenCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0001-6172-4211
Katja ParapaticsCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Vincent A BlomenNetherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.
André C MüllerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0002-0608-8176
Georg E WinterCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0001-6606-1437
Robert KralovicsCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Thijn R BrummelkampCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.ORCID 0000-0002-3066-7071
Marek MlodzikDepartment of Cell, Developmental, and Regenerative Biology and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Giulio Superti-FurgaCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. gsuperti@cemm.oeaw.ac.at.
Austrian Academy of Sciences · ATIcahn School of Medicine at Mount Sinai · USThe Netherlands Cancer Institute · NL
Funding
Retinal Patterning During Eye DevelopmentR01EY013256 · NEI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Marek Mlodzik · 2001 to 2026
$10.0MWnt/Frizzled-PCP signaling in development and diseaseR35GM127103 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Marek Mlodzik · 2018 to 2026
$5.6MPlanar Cell Polarity regulation by transmembrane proteinsR01GM102811 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MLODZIK, MAREK · 2012 to 2017
$2.1MAustrian Science Fund FWF F 4702Austrian Science Fund FWF F 4711NEI NIH HHS R01 EY013256NIGMS NIH HHS R01 GM102811NIGMS NIH HHS R35 GM127103
Abstract
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (
Indexed as
UbiquitinationAnimalsAntineoplastic AgentsCell Line, TumorDrosophila melanogasterDrug Resistance, NeoplasmFusion Proteins, bcr-ablGain of Function MutationGene Knockdown TechniquesHumansImidazolesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLoss of Function MutationMAP Kinase Signaling SystemProtein Kinase InhibitorsProto-Oncogene Proteins p21(ras)Antineoplastic AgentsFusion Proteins, bcr-ablImidazolesKRAS protein, humanLZTR1 protein, humanponatinibProtein Kinase InhibitorsProto-Oncogene Proteins p21(ras)PyridazinesTranscription Factors
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.