Evidence map›Paper›PMID 30442696›Full record

ArticleAJNR. American journal of neuroradiology2018

MRI, Magnetoencephalography, and Surgical Outcome of Oligodendrocytosis versus Focal Cortical Dysplasia Type I.

D Mata-Mbemba, Y Iimura, L-N Hazrati, A Ochi, H Otsubo, O C Snead, J Rutka, E Widjaja

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

D Mata-MbembaFrom the Department of Diagnostic Imaging (D.M.-M., E.W.).ORCID 0000-0002-0031-6473
Y IimuraDivision of Neurology (Y.I., A.O., H.O., O.C.S., E.W.).ORCID 0000-0003-4263-5920
L-N HazratiDepartments of Pathology (L.-N.H.).ORCID 0000-0003-2715-1485
A OchiDivision of Neurology (Y.I., A.O., H.O., O.C.S., E.W.).ORCID 0000-0002-6971-3987
H OtsuboDivision of Neurology (Y.I., A.O., H.O., O.C.S., E.W.).ORCID 0000-0002-4186-373X
O C SneadDivision of Neurology (Y.I., A.O., H.O., O.C.S., E.W.).ORCID 0000-0001-8910-0478
J RutkaNeurosurgery (J.R.), The Hospital for Sick Children, University of Toronto, Ontario, Canada.ORCID 0000-0003-0851-7330
E WidjajaFrom the Department of Diagnostic Imaging (D.M.-M., E.W.) Elysa.Widjaja@sickkids.ca.ORCID 0000-0003-0986-5476
Anna Needs Neuroblastoma Answers · USHospital for Sick Children · CAImaging Center · USInstituto Cajal · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAbnormalities of oligodendrocytes have been reported in surgical specimens of patients with medically intractable epilepsy. The aim of this study was to compare the MR imaging, magnetoencephalography, and surgical outcome of children with oligodendrocytosis relative to focal cortical dysplasia I. MATERIALS AND

methodsOligodendrocytosis included oligodendroglial hyperplasia, oligodendrogliosis, and oligodendroglial-like cells in the white matter, gray matter, or both from children with medically intractable epilepsy. Focal cortical dysplasia I included radial and tangential cortical dyslamination. The MR imaging, magnetoencephalography, type of operation, location, and seizure outcome of oligodendrocytosis, focal cortical dysplasia I, and oligodendrocytosis + focal cortical dysplasia I were compared.

resultsEighteen subjects (39.1%) had oligodendrocytosis, 21 (45.7%) had focal cortical dysplasia I, and 7 (15.2%) had oligodendrocytosis + focal cortical dysplasia I. There were no significant differences in the type of seizures, focal or nonfocal epileptiform discharges, magnetoencephalography, and MR imaging features, including high T1 signal in the cortex, high T2/FLAIR signal in the cortex or subcortical white matter, increased cortical thickness, blurring of the gray-white junction, or abnormal sulcation and gyration among those with oligodendrocytosis, focal cortical dysplasia I, or oligodendrocytosis + focal cortical dysplasia I (

conclusionsOligodendrocytosis shared MR imaging and magnetoencephalography features with focal cortical dysplasia I, and multilobar resection was frequently required to achieve seizure freedom. In 15% of cases, concurrent oligodendrocytosis and focal cortical dysplasia I were identified. The findings suggest that oligodendrocytosis may represent a mild spectrum of malformations of cortical development.

Indexed as

AdolescentBrainChildDrug Resistant EpilepsyFemaleHumansMagnetic Resonance ImagingMagnetoencephalographyMaleMalformations of Cortical DevelopmentOligodendrogliaRetrospective StudiesTreatment Outcome

Identifiers

PMID30442696
PMCPMC7655410
OpenAlexW2901074289

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.