ArticleAJNR. American journal of neuroradiology2018
Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 39 citations in OpenAlex.
- Alterations of White Matter Connectivity in Adults with Essential Hypertension.International journal of general medicine · 2024Trial
- Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.Stroke · 2026Article
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Increased Cerebral Vein Diameters Are Associated with Age and White Matter Hyperintensity.Biomedicines · 2026Article
- Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.medRxiv : the preprint server for health sciences · 2025Article
- Association of 206 Brain Structural Connectivity with Different Types of Strokes: A Mendelian Randomization Study.eNeuro · 2025Article
- Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk.Frontiers in neurology · 2025Article
- Association of the Brain White Matter Hyperintensity with the Cognitive Performance in Middle-Aged Population.Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms.Translational stroke research · 2024Review
- Integrating external summary information in the presence of prior probability shift: an application to assessing essential hypertension.Biometrics · 2024Article
- Association of Blood Pressure With Brain White Matter Microstructural Integrity Assessed With MRI Diffusion Tensor Imaging in Healthy Young Adults.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Abnormal brain diffusivity in participants with persistent neuropsychiatric symptoms after COVID-19.NeuroImmune pharmacology and therapeutics · 2023Article
- Supervised Phenotype Discovery From Multimodal Brain Imaging.IEEE transactions on medical imaging · 2023Article
- Diffusion in the corpus callosum predicts persistence of clinical symptoms after mild traumatic brain injury, a multi-scanner study.Frontiers in neuroimaging · 2023Article
- Frequency and predictive factors of minimal hepatic encephalopathy before and after sustained virological response in HCV cirrhosis.Clinical and experimental hepatology · 2022Article
- Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle-Aged Population.Journal of the American Heart Association · 2022Article
- Brain structure and perfusion in relation to serum renal function indexes in healthy young adults.Brain imaging and behavior · 2022Article
- Blood Pressure Rhythm and Blood Pressure Variability as Risk Factors for White Matter Lesions: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Characterizing CD38 Expression and Enzymatic Activity in the Brain of Spontaneously Hypertensive Stroke-Prone Rats.Frontiers in pharmacology · 2022Article
- Phenotype discovery from population brain imaging.Medical image analysis · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeTraditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease. MATERIALS AND
methodsThis was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adjusting for age, sex, and race and maximal linear regression models adjusting for cardiovascular risk factors were performed for regions meeting the Bonferroni threshold in the initial analysis.
resultsIncluded were 116 subjects (mean age, 49 ± 11 years; 57% men) with a moderate load of cardiovascular risk factors. Subjects with hypertension had significantly lower regional fractional anisotropy in the right cingulum and left stria terminalis in the minimal and maximal regression models. Additionally, there was lower regional fractional anisotropy in the left fornix in the maximal model and right sagittal stratum in the minimal model. Systolic blood pressure values were significantly associated with regional fractional anisotropy in the left superior longitudinal fasciculus in the maximal model. There were no significant differences among regional fractional anisotropy values for other cardiovascular risk factors.
conclusionsIn middle-aged apparently healthy individuals with susceptibility to vascular disease, among all known cardiovascular risk factors, hypertension was associated with microstructural WM disruption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.