Evidence map›Paper›PMID 30442683›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2019

Frederik Holst, Henrica M J Werner, Siv Mjøs, Erling A Hoivik, Kanthida Kusonmano, Elisabeth Wik, Anna Berg, Even Birkeland, William J Gibson, Mari K Halle and 8 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 4 countries.

Frederik HolstCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway. mail@frederikholst.org.ORCID 0000-0002-5928-2175
Henrica M J WernerCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Siv MjøsCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Erling A HoivikCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Kanthida KusonmanoCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-6532-9144
Elisabeth WikCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Anna BergCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Even BirkelandCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
William J GibsonDepartment of Cancer Biology and Department of Medical Oncology, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Boston, Massachusetts.
Mari K HalleCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Jone TrovikCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-3808-6407
Andrew D CherniackThe Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
Karl-Henning KallandCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Gordon B MillsDepartment of Systems Biology, MD Anderson Cancer Center, Houston, Texas.
Christian F SingerDepartment of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Camilla KrakstadCenter for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0002-0174-8139
Rameen Beroukhim *Department of Cancer Biology and Department of Medical Oncology, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Boston, Massachusetts.
Helga B Salvesen *Center for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Haukeland University Hospital · NOBroad Institute · USComprehensive Cancer Center Vienna · ATThe University of Texas MD Anderson Cancer Center · US

Funding

Targeting the PI3K Signaling Pathway in Endometrial CarcinomaP50CA098258 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BODURKA, DIANE · 2003 to 2020
$32.0M
Genetic evolution of glioblastomas during radiation and temozolomide therapyR01CA188228 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, CHAKRAVARTI, ARNAB · 2015 to 2025
$6.9M
NCI NIH HHS P50 CA098258NCI NIH HHS R01 CA188228
6 · The paper itself

Abstract

purposeAmplification of EXPERIMENTAL

designUCECs from 591 clinically annotated patients including 83 tumors with matching metastasis (

results

conclusions

Indexed as

PrognosisAgedBiomarkers, TumorClass I Phosphatidylinositol 3-KinasesDisease-Free SurvivalDNA Copy Number VariationsEndometrial NeoplasmsFemaleGene AmplificationGene Expression Regulation, NeoplasticHumansMiddle AgedMutationNeoplasm MetastasisPhenotypeProto-Oncogene Proteins c-aktBiomarkers, TumorClass I Phosphatidylinositol 3-KinasesMTOR protein, humanPIK3CA protein, humanProto-Oncogene Proteins c-aktRNA, MessengerTOR Serine-Threonine Kinases

Identifiers

PMID30442683
PMCPMC6384094
OpenAlexW2900864831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.