Evidence map›Paper›PMID 30442673›Full record

ArticleMolecular pharmacology2019

Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1

Carley J S Heck, Allyson N Hamlin, Namandjé N Bumpus

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Roles of X-box binding protein 1 in liver pathogenesis.Clinical and molecular hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Carley J S HeckDepartment of Pharmacology and Molecular Sciences (C.J.S.H., N.N.B.) and Department of Medicine, Division of Clinical Pharmacology (A.N.H., N.N.B.), Johns Hopkins University School of Medicine, Baltimore, Maryland.
Allyson N HamlinDepartment of Pharmacology and Molecular Sciences (C.J.S.H., N.N.B.) and Department of Medicine, Division of Clinical Pharmacology (A.N.H., N.N.B.), Johns Hopkins University School of Medicine, Baltimore, Maryland.
Namandjé N BumpusDepartment of Pharmacology and Molecular Sciences (C.J.S.H., N.N.B.) and Department of Medicine, Division of Clinical Pharmacology (A.N.H., N.N.B.), Johns Hopkins University School of Medicine, Baltimore, Maryland nbumpus1@jhmi.edu.
Johns Hopkins Medicine · US

Funding

PHARMACOLOGY TRAINING GRANTT32GM008763 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FREEL MEYERS, CAREN L. · 2000 to 2019
$6.1M
Cellular Signaling in Drug Induced ToxicityR01GM103853 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ORSBURN, BENJAMIN CARL · 2013 to 2022
$3.6M
NIGMS NIH HHS R01 GM103853NIGMS NIH HHS T32 GM008763
6 · The paper itself

Abstract

Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates the activation in primary hepatocytes of key cell stress regulators: inositol-requiring 1

Indexed as

AlkynesAnimalsBenzoxazinesCells, CulturedCyclopropanesEndoribonucleasesFemaleHepatocytesHumansLiverMacacaMaleMiceMice, Inbred C57BLPhosphorylationRNA Splicing8-hydroxyefavirenzAlkynesBenzoxazinesCyclopropanesefavirenzEndoribonucleasesTranscription FactorsX-Box Binding Protein 1

Identifiers

PMID30442673
PMCPMC6324649
OpenAlexW2901217387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.