Evidence map›Paper›PMID 30442667›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

The CD4

Joana Dias, Caroline Boulouis, Jean-Baptiste Gorin, Robin H G A van den Biggelaar, Kerri G Lal, Anna Gibbs, Liyen Loh, Muhammad Yaaseen Gulam, Wan Rong Sia, Sudipto Bari and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 169 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Avoidance of MAIT cells is an essential determinant ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. MAIT cell plasticity generates CD4Cellular & molecular immunology · 2026
    Article
  9. Article
  10. Mucosal-Associated Invariant T Cells in Rheumatic Diseases.Arthritis & rheumatology (Hoboken, N.J.) · 2026
    Review
  11. Gastrointestinal MAIT cells in chronic HIV-1 infection.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 5 countries.

Joana DiasDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Caroline BoulouisDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Jean-Baptiste GorinDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Robin H G A van den BiggelaarDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Kerri G LalDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Anna GibbsUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
Liyen LohDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110.
Muhammad Yaaseen GulamProgram in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169587 Singapore.
Wan Rong SiaProgram in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169587 Singapore.
Sudipto BariDepartment of Hematology, Singapore General Hospital, 169608 Singapore.
William Y K HwangDepartment of Hematology, Singapore General Hospital, 169608 Singapore.
Douglas F NixonDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110.ORCID 0000-0002-2801-1786
Son NguyenDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Michael R BettsDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Marcus BuggertDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.
Michael A EllerUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910.ORCID 0000-0003-3905-4877
Kristina BrolidenUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
Annelie TjernlundUnit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
Johan K SandbergDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden; johan.sandberg@ki.se edwin.leeansyah@ki.se.ORCID 0000-0002-6275-0750
Edwin LeeansyahDepartment of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden; johan.sandberg@ki.se edwin.leeansyah@ki.se.
Karolinska University Hospital · SENational University of Singapore · SGHenry M. Jackson Foundation · USUniversity of Pennsylvania · USSingapore General Hospital · SGThe University of Melbourne · AUUniversity of California, San Francisco · US

Funding

Intestinal MAIT Cells in HIV InfectionR01DK108350 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PAQUIN-PROULX, DOMINIC, SANDBERG, JOHAN K · 2015 to 2019
$2.5M
NIDDK NIH HHS R01 DK108350
6 · The paper itself

Abstract

Mucosa-associated invariant T (MAIT) cells are unconventional innate-like T cells that recognize microbial riboflavin metabolites presented by the MHC class I-like protein MR1. Human MAIT cells predominantly express the CD8α coreceptor (CD8

Indexed as

CD8-Positive T-LymphocytesFemaleFetusGene Expression RegulationHumansMaleNucleic Acid Amplification TechniquesPregnancyRNAT-Lymphocyte SubsetsUterusRNAapoptosisCD8functional heterogeneityMAIT cellsMR1

Identifiers

PMID30442667
PMCPMC6298106
OpenAlexW2900805423

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.