ArticleProceedings of the National Academy of Sciences of the United States of America2018
Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
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Who cites it
44 citing papers in PubMed.
- Amphioxus tyrosine kinase SYK inhibits NF-κB activation through MyD88-dependent mechanism.Journal of molecular cell biology · 2026Article
- The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.The EMBO journal · 2026Article
- Brain targeting and trafficking of extracellular vesicles in central nervous system diseases: a therapeutic roadmap.Nanomedicine (London, England) · 2026Review
- Microglial Dysfunction Induced by C9ORF72 Dipeptide Repeat Proteins: Biomarker and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Article
- Article
- Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Plasma Proteomics Reveals Persistent and Surgery-Responsive Molecular Signatures in Osteoarthritis Patients.International journal of molecular sciences · 2026Article
- Autoimmune Diseases and Mycobacterial Infection.Diseases (Basel, Switzerland) · 2026Review
- PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids.Brain : a journal of neurology · 2026Article
- Evolving strategies of intracellular HypervirulentVirulence · 2025Article
- The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis.bioRxiv : the preprint server for biology · 2025Article
- C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS-STING Pathway.Immunity, inflammation and disease · 2025Article
- Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn's Disease.bioRxiv : the preprint server for biology · 2024Article
- Altered X-chromosome inactivation predisposes to autoimmunity.Science advances · 2024Article
- Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence.Neural regeneration research · 2024Review
- Endosomal Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases.Advances in experimental medicine and biology · 2024Article
- The endolysosomal pathway and ALS/FTD.Trends in neurosciences · 2023Review
- Microbial sensing in the intestine.Protein & cell · 2023Review
- The dual lipid desaturase/hydroxylase DEGS2 controls phytoceramide levels necessary to counter intestinal inflammation.Disease models & mechanisms · 2023Article
Corrections and comments
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Authors and funding
21 authors.
William McAlpineCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Lei SunCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Kuan-Wen WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Aijie LiuCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Ruchi JainDivision of Gastroenterology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Miguel San MiguelDivision of Gastroenterology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Jianhui WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Zhao ZhangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Braden HayseCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Sarah Grace McAlpineCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Jin Huk ChoiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Xue ZhongCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Sara LudwigCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Jamie RussellCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Xiaoming ZhanCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Mihwa ChoiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Xiaohong LiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Miao TangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Eva Marie Y MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505.
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505; bruce.beutler@utsouthwestern.edu emre.turer@utsouthwestern.edu.ORCID 0000-0002-3639-246X
Emre TurerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505; bruce.beutler@utsouthwestern.edu emre.turer@utsouthwestern.edu.
Funding
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NOLAN, GARRY P · 2012 to 2021
$49.1MAutomated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5MINTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4MRNA POLYMERASE II TRANSCRIPTION SYSTEM FROM YEASTR37GM036659 · NIGMS · STANFORD UNIVERSITY · PI KORNBERG, ROGER D · 1998 to 2008
$4.6MForward Genetic Analysis of Intestinal HomeostasisK08DK107886 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TURER, EMRE EROL · 2016 to 2020
$740kThe Role of KBTBD2 in Lipodystrophy, Insulin Resistance, and DiabetesK99DK115766 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, ZHAO · 2017 to 2018
$182kNIAID NIH HHS R01 AI125581NIAID NIH HHS T32 AI005284NIAID NIH HHS U19 AI100627NIDDK NIH HHS K08 DK107886NIDDK NIH HHS K99 DK115766NIGMS NIH HHS R37 GM036659
Abstract
The SMCR8-WDR41-C9ORF72 complex is a regulator of autophagy and lysosomal function. Autoimmunity and inflammatory disease have been ascribed to loss-of-function mutations of
Indexed as
AnimalsAutoimmune DiseasesAutophagy-Related ProteinsC9orf72 ProteinCarrier ProteinsColitisDextran SulfateGene Expression RegulationHematopoiesisInflammationIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMutationSignal TransductionToll-Like ReceptorsAutophagy-Related ProteinsC9orf72 ProteinC9orf72 protein, mouseCarrier ProteinsDextran SulfateIntracellular Signaling Peptides and ProteinsSMCR8 protein, mouseToll-Like ReceptorsWDR41 protein, mouseinflammationinflammatory bowel diseaseToll-like receptorvesicle trafficking
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.