Evidence map›Paper›PMID 30442652›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Transient Receptor Potential Ion Channel-Dependent Toxicity of Silica Nanoparticles and Poly(amido amine) Dendrimers.

Raziye Mohammadpour, Mostafa Yazdimamaghani, Christopher A Reilly, Hamidreza Ghandehari

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Toxicity evaluation of silica nanoparticles for delivery applications.Drug delivery and translational research · 2023
    Review
  2. Review
  3. Article
  4. TRP Channels as Cellular Targets of Particulate Matter.International journal of molecular sciences · 2021
    Review
  5. Silica nanomaterials induce organ injuries by CaParticle and fibre toxicology · 2020
    Article
  6. Article
  7. Article
  8. Subchronic toxicity of silica nanoparticles as a function of size and porosity.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Raziye MohammadpourUtah Center for Nanomedicine, Nano Institute of Utah (R.M., M.Y., H.G.), Departments of Pharmaceutics and Pharmaceutical Chemistry (M.Y., H.G.), Pharmacology and Toxicology (C.A.R.), and Bioengineering (H.G.), University of Utah, Salt Lake City, Utah.
Mostafa YazdimamaghaniUtah Center for Nanomedicine, Nano Institute of Utah (R.M., M.Y., H.G.), Departments of Pharmaceutics and Pharmaceutical Chemistry (M.Y., H.G.), Pharmacology and Toxicology (C.A.R.), and Bioengineering (H.G.), University of Utah, Salt Lake City, Utah.
Christopher A ReillyUtah Center for Nanomedicine, Nano Institute of Utah (R.M., M.Y., H.G.), Departments of Pharmaceutics and Pharmaceutical Chemistry (M.Y., H.G.), Pharmacology and Toxicology (C.A.R.), and Bioengineering (H.G.), University of Utah, Salt Lake City, Utah chris.reilly@pharm.utah.edu.
Hamidreza GhandehariUtah Center for Nanomedicine, Nano Institute of Utah (R.M., M.Y., H.G.), Departments of Pharmaceutics and Pharmaceutical Chemistry (M.Y., H.G.), Pharmacology and Toxicology (C.A.R.), and Bioengineering (H.G.), University of Utah, Salt Lake City, Utah hamid.ghandehari@utah.edu.
University of Utah · US

Funding

TRP Channels and Air PollutionR01ES017431 · NIEHS · UNIVERSITY OF UTAH · PI REILLY, CHRISTOPHER A · 2009 to 2024
$5.3M
BIOLOGICAL FATE AND BIOCOMPATIBILITY OF SILICA-BASED NANOCONSTRUCTSR01ES024681 · NIEHS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Hamid Ghandehari · 2014 to 2026
$4.1M
Pulmonary Epithelial TRPV3 and Wood Smoke InjuryR01ES027015 · NIEHS · UNIVERSITY OF UTAH · PI REILLY, CHRISTOPHER A · 2017 to 2021
$1.7M
NIEHS NIH HHS R01 ES017431NIEHS NIH HHS R01 ES024681NIEHS NIH HHS R01 ES027015
6 · The paper itself

Abstract

Fundamental to the design and development of nanoparticles for applications in nanomedicine is a detailed understanding of their biologic fate and potential toxic effects. Transient receptor potential (TRP) ion channels are a large superfamily of cation channels with varied physiologic functions. This superfamily is classified into six related subfamilies: TRP canonical, TRP vanilloid (TRPV), TRP melastatin (TRPM), TRP ankyrin (TRPA), TRP polycystin, and TRP mucolipin. TRPA1, TRPM2, and TRPM8 are nonselective Ca

Indexed as

Cell SurvivalDendrimersHEK293 CellsHumansNanoparticlesPorositySilicon DioxideTransient Receptor Potential ChannelsTRPA1 Cation ChannelTRPM Cation ChannelsDendrimersPAMAM StarburstSilicon DioxideTransient Receptor Potential ChannelsTRPA1 Cation ChannelTRPA1 protein, humanTRPM2 protein, humanTRPM8 protein, humanTRPM Cation Channels

Identifiers

PMID30442652
PMCPMC6806633
OpenAlexW2901891337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.