SynthesisEBioMedicine2018
Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.Nature communications · 2021Pooled it
- Effect of maternal smoking during pregnancy on child blood pressure in a European cohort.Scientific reports · 2022Trial
- DNA Methylation and Fetal Programming of Cardiovascular Disease: From Congenital Heart Diseases to Adult Cardiovascular Dysfunction.Reviews in cardiovascular medicine · 2026Review
- Early life events may be the first steps on the multistep path to amyotrophic lateral sclerosis.Scientific reports · 2024Article
- Developmental origins of psycho-cardiometabolic multimorbidity in adolescence and their underlying pathways through methylation markers: a two-cohort study.European child & adolescent psychiatry · 2024Article
- Maternal smoking during pregnancy links to childhood blood pressure through birth weight and body mass index: NHANES 1999-2018.Journal of human hypertension · 2024Article
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- Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA).Clinical epigenetics · 2022Article
- Cohort Profile: 46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966).International journal of epidemiology · 2022Article
- Gene-Environment Interactions and Stochastic Variations in the Gero-Exposome.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years.Hypertension (Dallas, Tex. : 1979) · 2021Article
- DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.Environmental health perspectives · 2021Article
- DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children's Health.Clinical epigenetics · 2021Article
- Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project.PloS one · 2021Article
- Nicotine and Its Downstream Metabolites in Maternal and Cord Sera: Biomarkers of Prenatal Smoking Exposure Associated with Offspring DNA Methylation.International journal of environmental research and public health · 2020Article
- Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults.Environmental health perspectives · 2020Article
- Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer.Clinical epigenetics · 2020Article
- Cadmium, Smoking, and Human Blood DNA Methylation Profiles in Adults from the Strong Heart Study.Environmental health perspectives · 2020Article
- Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk.Frontiers in genetics · 2019Article
- Mother smoking leads to methylation anomalies on 'smoke' genes in the offspring: Indelible traces of previous injuries.EBioMedicine · 2018Article
Corrections and comments
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Authors and funding
68 authors at 20 institutions in 12 countries.
Priyanka ParmarCenter for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
Estelle LowryCenter for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
Giovanni CugliariDepartment of Medical Sciences, University of Turin, Turin, Italy; Italian Institute for Genomic Medicine, IIGM, Turin, Italy.
Matthew SudermanMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK.
Rory WilsonResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Bavaria, Germany; Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany.
Ville KarhunenDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London.
Toby AndrewGenomics of Common Disease, Department of Medicine, Imperial College London, London, UK.
Petri WiklundCenter for Life Course Health Research, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London.
Simonetta GuarreraDepartment of Medical Sciences, University of Turin, Turin, Italy; Italian Institute for Genomic Medicine, IIGM, Turin, Italy.
Alexander TeumerDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; Partner Site Greifswald, DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Benjamin LehneDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London.
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden.
Niek de KleinDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Pashupati P MishraDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Centre - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Phillip E MeltonSchool of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia; Curtin UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia, Crawley, Australia.
Pooja R MandaviyaDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Silva KaselaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Jana NanoHelmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany; Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Weihua ZhangDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Cardiology, Ealing Hospital, North West Healthcare NHS Trust, London, UK.
Yan ZhangDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Annette PetersResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Bavaria, Germany; Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany; Network Aging Research, University of Heidelberg, Bergheimer Straße, Heidelberg, Germany.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Bavaria, Germany; Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Denise AndersonTelethon Kids Institute, University of Western Australia, Perth, Australia.
Dorret I BoomsmaDepartment of Biological Psychology, School of Public Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases DZNE, Site Rostock/Greifswald, Greifswald, Germany.
Salvatore PanicoDepartment of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Jan H VeldinkDepartment of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Leonard van den BergDepartment of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Lawrence J BeilinMedical School, University of Western Australia, Perth, Australia.
Lude FrankeDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Marie LohDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, Singapore; Institute of Health Sciences, University of Oulu, Finland.
Marleen M J van GreevenbroekDepartment of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands.
Matthias NauckPartner Site Greifswald, DZHK (German Centre for Cardiovascular Research), Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Centre - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Mikko A HurmeDepartment of Microbiology and Immunology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
P Eline SlagboomMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
Pim van der HarstDepartment of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands; Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands; Durrer Centre for Cardiogenetic Research, ICIN - Netherlands Heart Institute, Utrecht, The Netherlands.
Sonja KunzeResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Bavaria, Germany; Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany.
Stephan B FelixPartner Site Greifswald, DZHK (German Centre for Cardiovascular Research), Greifswald, Germany.
Tao ZhangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA; Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
Wei ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA.
Trevor A MoriMedical School, University of Western Australia, Perth, Australia.
Amelie BonnefondGenomics of Common Disease, Department of Medicine, Imperial College London, London, UK; European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, CNRS UMR 8199, Lille, France.
Bastiaan T HeijmansMolecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
BIOS Consortium
Taulant MukaDepartment of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, North West Healthcare NHS Trust, London, UK; Imperial College Healthcare NHS Trust, London, UK; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Imperial College London, National Heart and Lung Institute, London, UK.
Krista FischerEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Bavaria, Germany; Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Philippe FroguelGenomics of Common Disease, Department of Medicine, Imperial College London, London, UK; European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, CNRS UMR 8199, Lille, France.
Rae-Chi HuangTelethon Kids Institute, University of Western Australia, Perth, Australia.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Centre - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Wolfgang RathmannInstitute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich, Heine University, Düsseldorf, Germany.
Caroline L ReltonMRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK.
Giuseppe MatulloDepartment of Medical Sciences, University of Turin, Turin, Italy; Italian Institute for Genomic Medicine, IIGM, Turin, Italy.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany; Network Aging Research, University of Heidelberg, Bergheimer Straße, Heidelberg, Germany.
Niek VerweijDepartment of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Shengxu LiChildren's Hospitals and Clinics of Minnesota, Children's Minnesota Research Institute, Minneapolis, MN 55404, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Cardiology, Ealing Hospital, North West Healthcare NHS Trust, London, UK; Imperial College Healthcare NHS Trust, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Marjo-Riitta JärvelinCenter for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK. Electronic address: m.jarvelin@imperial.ac.uk.
Sylvain SebertCenter for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Medical Research Centre (MRC) Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland. Electronic address: sylvain.sebert@oulu.fi.
GLOBAL Meth QTL Consortium
Helmholtz Zentrum München · DEImperial College London · GBErasmus University Rotterdam · NLTampere University · FIUniversity Medical Center Groningen · NLGerman Cancer Research Center · DEImperial College Healthcare NHS Trust · GBItalian institute for Genomic Medicine · ITThe University of Western Australia · AUUniversitätsmedizin Greifswald · DECentre National de la Recherche Scientifique · FRLeiden University Medical Center · NLOulu University of Applied Sciences · FIThe Kids Research Institute Australia · AUTulane University · USUniversity Medical Center Utrecht · NLUniversity of Bristol · GBUniversity of Tartu · EEAgency for Science, Technology and Research · SGChildren's Minnesota · US
Funding
Medical Research Council G0601966Medical Research Council G0700931Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/8Medical Research Council MR/M013138/1Medical Research Council MR/M013138/2
Abstract
backgroundDNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.
methodsWe meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n = 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), diastolic, and systolic blood pressure (BP).
findingsLower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P < 0·012. In contrast, lower DNA methylation at cg09935388, the strongest adult own smoking locus, was associated with decreased BMI, WC, and BP (adjusted 1 × 10
interpretationEpigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. FUND: European Union's Horizon 2020 research and innovation programme under grant agreement no. 633595 DynaHEALTH.
Indexed as
Disease SusceptibilityGenetic LociPhenotypePrenatal Exposure Delayed EffectsAdultBiomarkersCpG IslandsDNA-Binding ProteinsDNA MethylationEnergy MetabolismEpigenesis, GeneticFemaleHumansMaleMaternal ExposureMiddle AgedBiomarkersDNA-Binding ProteinsGFI1 protein, humanTranscription Factors
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