Evidence map›Paper›PMID 30442286›Full record

ArticleJournal of the American College of Cardiology2018

Differences in Risk of Sudden Cardiac Death Between Blacks and Whites.

Rajat Deo, Monika M Safford, Yulia A Khodneva, Deanna P Jannat-Khah, Todd M Brown, Suzanne E Judd, William M McClellan, J David Rhodes, Michael G Shlipak, Elsayed Z Soliman and 1 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American College of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Health Disparities and Cardiovascular Disease.Healthcare (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rajat DeoElectrophysiology Section, Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: Rajat.Deo@uphs.upenn.edu.
Monika M SaffordDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
Yulia A KhodnevaDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Deanna P Jannat-KhahDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York.
Todd M BrownDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Suzanne E JuddDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
William M McClellanDepartments of Medicine and Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
J David RhodesDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Michael G ShlipakDepartment of Epidemiology, Biostatistics, and Medicine, University of California San Francisco, San Francisco, California; Department of General Internal Medicine, San Francisco VA Medical Center, San Francisco, California.
Elsayed Z SolimanEpidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, and Department of Internal Medicine, Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina.
Christine M AlbertCenter for Arrhythmia Prevention, Division of Preventive Medicine, and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
Building Capacity for Cardiometabolic Outcomes ResearchK24HL111154 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAFFORD, MONIKA M · 2012 to 2015
$556k
AHRQ HHS T32 HS013852NHLBI NIH HHS K24 HL111154NHLBI NIH HHS R01 HL080477NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundPrior studies have consistently demonstrated that blacks have an approximate 2-fold higher incidence of sudden cardiac death (SCD) than whites; however, these analyses have lacked individual-level sociodemographic, medical comorbidity, and behavioral health data.

objectivesThe purpose of this study was to evaluate whether racial differences in SCD incidence are attributable to differences in the prevalence of risk factors or rather to underlying susceptibility to fatal arrhythmias.

methodsThe Reasons for Geographic and Racial Differences in Stroke study is a prospective, population-based cohort of adults from across the United States. Associations between race and SCD defined per National Heart, Lung, and Blood Institute criteria were assessed.

resultsAmong 22,507 participants (9,416 blacks and 13,091 whites) without a history of clinical cardiovascular disease, there were 174 SCD events (67 whites and 107 blacks) over a median follow-up of 6.1 years (interquartile range: 4.6 to 7.3 years). The age-adjusted SCD incidence rate (per 1,000 person-years) was higher in blacks (1.8; 95% confidence interval [CI]: 1.4 to 2.2) compared with whites (0.7; 95% CI: 0.6 to 0.9), with an unadjusted hazard ratio of 2.35; 95% CI: 1.74 to 3.20. The association of black race with SCD risk remained significant after adjustment for sociodemographics, comorbidities, behavioral measures of health, intervening cardiovascular events, and competing risks of non-SCD mortality (hazard ratio: 1.97; 95% CI: 1.39 to 2.77).

conclusionsIn a large biracial population of adults without a history of cardiovascular disease, SCD rates were significantly higher in blacks as compared with whites. These racial differences were not fully explained by demographics, adverse socioeconomic measures, cardiovascular risk factors, and behavioral measures of health.

Indexed as

AgedAlcohol DrinkingArrhythmias, CardiacBlack or African AmericanBlack PeopleCohort StudiesDeath, Sudden, CardiacFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRisk FactorsSmokingUnited Statesepidemiologypopulation scienceracerisk factorrisk stratificationsudden cardiac death

Identifiers

PMID30442286
PMCPMC9704756

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.