Evidence map›Paper›PMID 30442192›Full record

ArticleBMC research notes2018

First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor.

Richard Fjellaksel, Ana Oteiza, Montserrat Martin-Armas, Patrick J Riss, Ole Kristian Hjelstuen, Samuel Kuttner, Jørn H Hansen, Rune Sundset

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Richard FjellakselMedical Imaging Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway. richard.fjellaksel@uit.no.ORCID http://orcid.org/0000-0002-6783-5198
Ana OteizaMedical Imaging Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Montserrat Martin-ArmasMedical Imaging Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Patrick J RissDepartment of Neuropsychiatry and Psychosomatic Medicine, Oslo University Hospital, Oslo, Norway.
Ole Kristian HjelstuenDrug Transport and Delivery Research Group, Department of Pharmacy, UiT The Arctic University of Norway, Tromsø, Norway.
Samuel KuttnerMedical Imaging Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Jørn H HansenOrganic Chemistry Research Group, Department of Chemistry, UiT The Arctic University of Norway, Tromsø, Norway.
Rune SundsetMedical Imaging Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
University Hospital of North Norway · NOUiT The Arctic University of Norway · NOOslo University Hospital · NO

Funding

Helse Nord RHF SFP1196-14
6 · The paper itself

Abstract

objectivesIn vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.

resultsWe have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature findings showed similar alpha-halogenated compounds suitable for in vivo evaluations. The compound was found to possess nano molar affinity for the gonadotropin releasing hormone-receptor in a competition dependent inhibition study. Furthermore, liquid chromatography-mass spectrometry analysis in saline, human and rat serum resulted in 46%, 52% and 44% stability after incubation for 1 h respectively. In addition, rat brain single photon emission computed tomography and biodistribution studies gave further insight into the nature of the compound as a radiotracer.

Indexed as

AnimalsBrainHumansHydrocarbons, HalogenatedIodine RadioisotopesKineticsMolecular StructureRatsReceptors, LHRHTissue DistributionTomography, Emission-Computed, Single-PhotonGNRHR protein, humanHydrocarbons, HalogenatedIodine RadioisotopesReceptors, LHRHAlpha-halogenationGnRHGonadotropinRadiotracerSPECT

Identifiers

PMID30442192
PMCPMC6238273
OpenAlexW2901936164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.