Evidence map›Paper›PMID 30442186›Full record

ArticleSystematic reviews2018

Safety and efficacy of Momordica charantia Linnaeus in pre-diabetes and type 2 diabetes mellitus patients: a systematic review and meta-analysis protocol.

Emanuel L Peter, Serawit Deyno, Andrew Mtewa, Félicien Mushagalusa Kasali, Prakash B Nagendrappa, Duncan Sesaazi, Casim Umba Tolo, Patrick Engeu Ogwang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Unlocking the anti-diabetic potential ofFood science & nutrition · 2023
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 6 countries.

Emanuel L PeterPharm-BioTechnology and Traditional Medicine Center, World Bank-Africa Center of Excellence (ACE II), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda. epeter@std.must.ac.ug.ORCID 0000-0002-8162-4784
Serawit DeynoPharm-BioTechnology and Traditional Medicine Center, World Bank-Africa Center of Excellence (ACE II), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Andrew MtewaPharm-BioTechnology and Traditional Medicine Center, World Bank-Africa Center of Excellence (ACE II), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Félicien Mushagalusa KasaliPharm-BioTechnology and Traditional Medicine Center, World Bank-Africa Center of Excellence (ACE II), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Prakash B NagendrappaSchool of Integrative Health Sciences, Trans-disciplinary University, Bengaluru, India.
Duncan SesaaziPharm-BioTechnology and Traditional Medicine Center, World Bank-Africa Center of Excellence (ACE II), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Casim Umba ToloPharm-BioTechnology and Traditional Medicine Center, World Bank-Africa Center of Excellence (ACE II), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Patrick Engeu OgwangPharm-BioTechnology and Traditional Medicine Center, World Bank-Africa Center of Excellence (ACE II), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.
Mbarara University of Science and Technology · UGUniversity of Trans-Disciplinary Health Sciences and Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMomordica charantia Linnaeus (Cucurbitaceae) has been used traditionally as a nutritious food and as a herbal medicine for type 2 diabetes mellitus. However, human studies that investigated its glycemic control have generated inconsistent findings. Therefore, this systematic review and meta-analysis is aimed at evaluating the safety and efficacy of M. charantia L. preparations in human studies that have investigated its role in glycemic control.

methodsThis protocol has been prepared according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The review will include randomized clinical trials and non-randomized clinical trials. The included studies will have assessed glycemic control of M. charantia preparations with placebo or standard oral anti-hyperglycemic agents in adult pre-diabetes and/or type 2 diabetes mellitus patients and have at least 4 weeks of follow-up. The primary outcomes of review are fasting blood glucose levels, glycosylated hemoglobin A1c, and post-prandial blood glucose level. Electronic database search for published literatures will be conducted without language restriction in EMBASE, MEDLINE/PubMed, the Cochrane Library, SCOPUS, Web of Sciences, and CINAHL databases. Search for gray literatures and references of the retrieved full-text articles will be conducted in Google, Google Scholar, OpenGrey, ProQuest dissertations & Theses, British Library EThos, and university digital library systems. Two independent reviewers will later evaluate full texts, extract data, and assess risk of bias of eligible articles. Publication biases will be assessed by testing asymmetry of funnel plot using Egger's or Begg's tests while heterogeneity will be assessed using Cochran Q test, P value, and I DISCUSSION: This systematic review and meta-analysis will investigate both safety and efficacy of M. charantia preparations in type 2 diabetes mellitus. The review results will be published in a peer-reviewed journal. The results will bring better understanding of clinical outcomes in treatment of type 2 diabetes mellitus patients and highlight gaps for future research. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018083653 .

Indexed as

Diabetes Mellitus, Type 2Hypoglycemic AgentsMomordica charantiaPhytotherapyPrediabetic StateBlood GlucoseGlycated HemoglobinHumansMeta-Analysis as TopicPlant PreparationsSystematic Reviews as TopicBlood GlucoseGlycated HemoglobinHypoglycemic AgentsPlant PreparationsBitter gourdMeta-analysisNIDDMProtocolSystematic review

Identifiers

PMID30442186
PMCPMC6238397
OpenAlexW2901207011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.