Evidence map›Paper›PMID 30442182›Full record

ArticleBMC research notes2018

Evaluation of CD38 expression in Sudanese patients with chronic lymphocytic leukemia.

Enaam Abdelrhman Abdelgader, Nada Hassan Eltayeb, Tasniem Ahmed Eltahir, Osama Ali Altayeb, Eman Abbass Fadul, Eldirdiri M Abdel Rahman, Tarig H Merghani

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In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Enaam Abdelrhman AbdelgaderDepartment of Pathology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan. enaamresearch@gmail.com.
Nada Hassan EltayebDepartment of Physiology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan.
Tasniem Ahmed EltahirKhartoum Radioisotope Center, Khartoum, Sudan.
Osama Ali AltayebFlow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan.
Eman Abbass FadulFlow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan.
Eldirdiri M Abdel RahmanKhartoum Radioisotope Center, Khartoum, Sudan.
Tarig H MerghaniDepartment of Physiology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to evaluate the cluster of differentiation-38 (CD38) expression in Sudanese patients with chronic lymphocytic leukemia (CLL) and to determine its association with clinical and laboratory characteristics of the disease.

resultsWe conducted a cross-sectional study on 99 patients diagnosed with CLL in Khartoum Oncology Hospital in Khartoum, Sudan. Immunophenotyping and CD38 expression levels were measured with four-color flowcytometry. The results of physical examination and blood analyses were used for assigning a modified Rai clinical staging system. The collected data were analyzed using the Statistical Package for the Social Science, version 22 (SPSS Inc., Chicago, IL, USA). According to our findings, the frequencies of 7%, 20%, and 30% cutoff levels of CD38 expressions were 68.7%, 41.4%, and 36.4% respectively. CD38 cutoff level of 7% showed a significant association with hemoglobin concentration (P = 0.04), whereas other cutoff levels showed insignificant results. All the three cutoff levels showed insignificant associations with the other clinical and laboratory variables. In conclusion, the CD38 expression at a cutoff level of 7% seems to be more valuable clinically than higher cutoff levels in Sudanese CLL patients.

Indexed as

ADP-ribosyl Cyclase 1AdultAgedAged, 80 and overCross-Sectional StudiesFemaleFlow CytometryHumansImmunophenotypingLeukemia, Lymphocytic, Chronic, B-CellMaleMembrane GlycoproteinsMiddle AgedPrognosisSudanADP-ribosyl Cyclase 1CD38 protein, humanMembrane GlycoproteinsCD38CLLFlowcytometerLeukemia

Identifiers

PMID30442182
PMCPMC6238334

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.