Evidence map›Paper›PMID 30442153›Full record

ArticleJournal of neuroinflammation2018

Ca

Zhihua Yu, Fangfang Dou, Yanxia Wang, Lina Hou, Hongzhuan Chen

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. KCurrent neuropharmacology · 2023
    Review
  10. AβCellular and molecular life sciences : CMLS · 2022
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Alzheimer's Disease and Protein Kinases.Advances in experimental medicine and biology · 2021
    Article
  18. TheToxins · 2020
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zhihua YuDepartment of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, China. yuzhihua@shsmu.edu.cn.
Fangfang DouBasic Research Department, Shanghai Geriatric Institute of Chinese Medicine, Shanghai, 200031, China.
Yanxia WangExperimental Teaching Center of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Lina HouDepartment of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, China.
Hongzhuan ChenDepartment of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, China. hongzhuan-chen@hotmail.com.
Shanghai Jiao Tong University · CNShanghai University of Traditional Chinese Medicine · CNYangPu Geriatric Hospital · CN

Funding

National Natural Science Foundation of China (CN) 81773699Science and Technology Commission of Shanghai Municipality grant 16ZR1418700
6 · The paper itself

Abstract

backgroundThe intermediate-conductance Ca

methodsKCa3.1 channels expression and cell localization in the brains of AD patients and APP/PS1 mice model were measured by immunoblotting and immunostaining. APP/PS1 mice and KCa3.1

resultsKCa3.1 expression was markedly associated with endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in both Aβ-stimulated primary astrocytes and brain lysates of AD patients and APP/PS1 AD mice. The KCa3.1 channel was shown to regulate store-operated Ca

conclusionsOverall, these results suggest that KCa3.1 is involved in the regulation of Ca

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsAnimals, NewbornCalciumCells, CulturedEndoplasmic Reticulum StressFemaleGene Expression RegulationGliosisHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsMaleMaze LearningAmyloid beta-Protein PrecursorCalciumIntermediate-Conductance Calcium-Activated Potassium ChannelsKCNN4 protein, humanOncogene Protein v-aktPresenilin-1Alzheimer’s diseaseEndoplasmic reticulum stressKCa3.1Mouse modelUnfolded protein response

Identifiers

PMID30442153
PMCPMC6236981
OpenAlexW2900486283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.