ArticleEnvironmental health : a global access science source2018
Safety of Safety Evaluation of Pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl.
Article in Environmental health : a global access science source, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026Review
- Urinary pesticide profiles and liver disease risk in Thailand: a machine-learning risk-prediction model.medRxiv : the preprint server for health sciences · 2025Article
- Glyphosate exposure and GM seed rollout unequally reduced perinatal health.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chlorpyrifos Acts as a Positive Modulator and an Agonist ofJournal of xenobiotics · 2025Article
- Developing a Multi-Spectral NIR LED-Based Instrument for the Detection of Pesticide Residues Containing Chlorpyrifos-Methyl in Rough, Brown, and Milled Rice.Sensors (Basel, Switzerland) · 2024Article
- Non-disclosure of developmental neurotoxicity studies obstructs the safety assessment of pesticides in the European Union.Environmental health : a global access science source · 2023Article
- Conducting evaluations of evidence that are transparent, timely and can lead to health-protective actions.Environmental health : a global access science source · 2022Article
- Chlorpyrifos Occurrence and Toxicological Risk Assessment: A Review.International journal of environmental research and public health · 2022Review
- What you don't know can still hurt you - underreporting in EU pesticide regulation.Environmental health : a global access science source · 2022Article
- Using R in Regulatory Toxicology.EXCLI journal · 2022Article
- Tyrosinase-mediated synthesis of larvicidal active 1,5-diphenyl pent-4-en-1-one derivatives against Culex quinquefasciatus and investigation of their ichthyotoxicity.Scientific reports · 2021Article
- Gene-Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres.Environmental health perspectives · 2021Article
- Co-expression network of long non-coding RNA and mRNA reveals molecular phenotype changes in kidney development of prenatal chlorpyrifos exposure in a mouse model.Annals of translational medicine · 2021Article
- Resistance development characteristics of reared German cockroach (Blattodea: Blattellidae) to chlorpyrifos.Scientific reports · 2021Article
- Effects of chlorpyrifos exposure on liver inflammation and intestinal flora structure in mice.Toxicology research · 2021Article
- Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model.Archives of toxicology · 2021Article
- A sensing approach for automated and real-time pesticide detection in the scope of smart-farming.Computers and electronics in agriculture · 2020Article
- Application of the Food Quality Protection Act children's health safety factor in the U.S. EPA pesticide risk assessments.Environmental health : a global access science source · 2020Article
- Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development.European thyroid journal · 2019Review
- Updated statement on the available outcomes of the human health assessment in the context of the pesticides peer review of the active substance chlorpyrifos-methyl.EFSA journal. European Food Safety Authority · 2019Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Authorization of pesticides for market release requires toxicity testing on animals, typically performed by test laboratories on contract with the pesticide producer. The latter provides the results and summary to the regulatory authorities. For the commonly used pesticide chlorpyrifos, an industry-funded toxicity study concludes that no selective effects on neurodevelopment occur even at high exposures. In contrast, the evidence from independent studies points to adverse effects of current exposures on cognitive development in children. We reviewed the industry-funded developmental neurotoxicity test data on chlorpyrifos and the related substance chlorpyrifos-methyl. We noted treatment-related changes in a brain dimension measure for chlorpyrifos at all dose levels tested, although not been reported in the original test summary. We further found issues which inappropriately decrease the ability of the studies to reveal true effects, including a dosage regimen that resulted in too low exposure of the nursing pups for chlorpyrifos and possibly for chlorpyrifos-methyl, and a failure to detect any neurobehavioral effects of lead nitrate used as positive control in the chlorpyrifos study. Our observations thus suggest that conclusions in test reports submitted by the producer may be misleading. This discrepancy affects the ability of regulatory authorities to perform a valid and safe evaluation of these pesticides. The difference between raw data and conclusions in the test reports indicates a potential existence of bias that would require regulatory attention and possible resolution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.