ArticleBMC cancer2018
Multidisciplinary treatment for patients with stage IV gastric cancer: the role of conversion surgery following chemotherapy.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- From Control to Conversion: Optimizing Systemic Therapy for Curative-Intent Conversion Surgery in Metastatic Gastric Cancer.Journal of gastric cancer · 2026Review
- Conversion Surgery After Trastuzumab-Based Chemotherapy and Immunotherapy for Stage IV HER2-Positive Gastric Cancer: A Retrospective Multicenter Cohort Study.Annals of surgical oncology · 2025Article
- Review
- Quadruple therapy with immunotherapy and chemotherapy as first-line conversion treatment for unresectable advanced gastric adenocarcinoma: A case report.World journal of gastrointestinal oncology · 2025Article
- Successful R0 resection after chemotherapy, including nivolumab, for gastric cancer with liver metastases: three case reports.Surgical case reports · 2024Article
- Conversion surgery for stage IV gastric cancer with multiple liver metastases with a complete pathological response to S-1 plus oxaliplatin therapy.Clinical journal of gastroenterology · 2024Article
- Prognostic factors of conversion surgery for stage IV gastric cancer: A multi-institutional retrospective analysis.Annals of gastroenterological surgery · 2024Article
- Survival benefits of adjuvant chemotherapy after conversion surgery in patients with advanced pancreatic cancer.Frontiers in oncology · 2024Article
- Clinical outcomes of conversion surgery following immune checkpoint inhibitors and chemotherapy in stage IV gastric cancer.International journal of surgery (London, England) · 2023Article
- The Clinical Implication of Conversion Surgery in Patients with Stage IV Gastric Cancer Who Received Systemic Chemotherapy.Biomedicines · 2023Article
- Genomic and evolutionary characteristics of metastatic gastric cancer by routes.British journal of cancer · 2023Article
- A prognostic scoring system for conversion surgery after trastuzumab-based chemotherapy for human epidermal growth factor receptor 2-positive advanced gastric cancer.Surgery today · 2022Article
- Conversion surgery for microsatellite instability-high gastric cancer with a complete pathological response to pembrolizumab: a case report.World journal of surgical oncology · 2022Article
- Outcomes of Conversion Surgery for Metastatic Gastric Cancer Compared with In-Front Surgery Plus Palliative Chemotherapy or In-Front Surgery Alone.Journal of personalized medicine · 2022Article
- The Prognostic Effect of Multidisciplinary Team Intervention in Patients with Advanced Gastric Cancer.Current oncology (Toronto, Ont.) · 2022Article
- Structured and shared CT radiological report of gastric cancer: a consensus proposal by the Italian Research Group for Gastric Cancer (GIRCG) and the Italian Society of Medical and Interventional Radiology (SIRM).European radiology · 2022Article
- Survival benefit of surgical resection for stage IV gastric cancer: A SEER-based propensity score-matched analysis.Frontiers in surgery · 2022Article
- Prognostic impact of surgery after chemotherapy for type 4 gastric cancer.Surgery today · 2021Article
- Current status of conversion surgery for stage IV gastric cancer.Surgery today · 2021Review
- Conversion surgery of Stage IV gastric cancer with peritoneal dissemination after nivolumab.International cancer conference journal · 2021Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following chemotherapy for patients with stage IV gastric cancer.
methodsWe retrospectively reviewed clinico-pathologic variables and oncologic outcomes for 101 patients with stage IV gastric cancer who were treated with systemic chemotherapy followed by gastrectomy with intension of curative resection from January 2005 to December 2012.
resultsIn terms of the best response from palliative chemotherapy, complete or partial response were observed in 65 patients (64.4%) in overall. Complete response of metastatic site were observed in 72 (71.3%) and 66 (65.3%) patients as best and pre-operative response, respectively. The overall complete macroscopic resection, rate was 56.4%. Eleven patients (10.9%) received combined metastasectomy. There was no postoperative surgery-related mortality for 1 month. The median overall survival time was 26.0 months. Multivariable analysis identified complete macroscopic resection, chemotherapy response (complete response/partial response) of metastatic sites, and change in CEA level as independent prognostic factors contributing to overall survival.
conclusionsPatients with stage IV gastric cancer who exhibit a good clinical response to chemotherapy might obtain greater survival benefit from gastrectomy following chemotherapy compared with patients who exhibit a poor response to chemotherapy. Prospective, randomized trials are required to determine the best strategy for combining initial chemotherapy with subsequent gastrectomy.
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