Evidence map›Paper›PMID 30441852›Full record

ArticleBiomolecules2018

Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction.

Maliha Zahid, Kyle S Feldman, Gabriel Garcia-Borrero, Timothy N Feinstein, Nicholas Pogodzinski, Xinxiu Xu, Raymond Yurko, Michael Czachowski, Yijen L Wu, Neale S Mason and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 57 citations in OpenAlex.

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  13. Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review.International journal of molecular sciences · 2024
    Review
  14. Current RNA strategies in treating cardiovascular diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Maliha ZahidDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. maz7@pitt.edu.
Kyle S FeldmanDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. ksf23@pitt.edu.
Gabriel Garcia-BorreroDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. gag44@pitt.edu.
Timothy N FeinsteinDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. tnf8@pitt.edu.
Nicholas PogodzinskiDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. nrp30@pitt.edu.
Xinxiu XuDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. xux@pitt.edu.
Raymond YurkoPeptide Synthesis Facility, University of Pittsburgh, Pittsburgh, PA 15201, USA. yurko@pitt.edu.
Michael CzachowskiDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA 15201, USA. michael.czachowski@chp.edu.
Yijen L WuDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. yijenwu@pitt.edu.
Neale S MasonDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA 15201, USA. masonns@upmc.edu.
Cecilia W LoDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, PA 15201, USA. cel36@pitt.edu.
University of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous work identified a 12-amino acid peptide that targets the heart, termed cardiac targeting peptide (CTP). We now quantitatively assess the bio-distribution of CTP, show a clinical application with the imaging of the murine heart, and study its mechanisms of transduction. Bio-distribution studies of cyanine5.5-

Indexed as

Tomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedTransduction, GeneticAnimalsHumansInduced Pluripotent Stem CellsLigandsMiceMyocardiumMyocytes, CardiacPeptidesRNA, Small InterferingTechnetiumTissue DistributionTransferrinLigandsPeptidesRNA, Small InterferingTechnetiumTransferrinbio-distributioncardiac targeting peptidecell penetrating peptidesmechanism of transductionprotein transduction domainsSPECT imaging

Identifiers

PMID30441852
PMCPMC6315548
OpenAlexW2900974820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.