ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2018
Cross-linked electrospun gelatin nanofibers for cell-based assays.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Low-cost gelatin/collagen scaffolds for bacterial growth in bioreactors for biotechnology.Applied microbiology and biotechnology · 2025Article
- Chondrogenic potential of PMSCs cultured on chondroitin sulfate/gelatin-modified DBM scaffold.BioImpacts : BI · 2025Article
- Electrospun hydrogels for dynamic culture systems: advantages, progress, and opportunities.Biomaterials science · 2021Review
- Non-Toxic Crosslinking of Electrospun Gelatin Nanofibers for Tissue Engineering and Biomedicine-A Review.Polymers · 2021Review
- Gelatin Matrices for Growth Factor Sequestration.Trends in biotechnology · 2020Review
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Authors and funding
2 authors.
Funding
Abstract
The present study evaluates the crosslinking of electrospun gelatin nanofibers by physical and chemical methods to further elucidate the importance of the application of gelatin scaffold platforms for cell-based assays. The dehydrothermally cross-linked electrospun gelatin scaffolds were unable to retained their structure morphology and integrity upon exposure to 1X PBS or cell-culture media. The DHT and EDC/Sulfo-NHS cross-linked gelatin scaffolds exhibited fiber diameter on average in the nanometer range. Subsequently, we utilized 1X PBS and cell culture media to evaluate the stability of the nanofibers in solution. The immersion evaluation indicated that the chemically crosslinked gelatin nanofibers maintained their random nanofiber distribution and morphology. However, a high degree of swelling was observed in the presence of cell culture media. Overall, the gelatin scaffold demonstrated good performance in PBS and cell culture media. Hence, EDC/Sulfo-NHS crosslinked electrospun gelatin nanofibrous scaffolds have good biocompatibility and are promising bio-scaffolds for cell-based assays.
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Registered trials
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