ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2018
Application of Parylene-Based Flexible Multi-Electrode Array for Recording From Subcortical Brain Regions From Behaving Rats.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Systematic evaluation of surgical insertion of flexible neural probe arrays into deeper brain targets using length modulation methods.Journal of neural engineering · 2026Article
- A Comprehensive Research Dissemination Model for Polymer-Based Neural Interfaces.IEEE transactions on bio-medical engineering · 2026Article
- Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- An Open-Source Wireless Electrophysiological Complex for In Vivo Recording Neuronal Activity in the Rodent's Brain.Sensors (Basel, Switzerland) · 2021Article
- A Bidirectional Neural Interface SoC With Adaptive IIR Stimulation Artifact Cancelers.IEEE journal of solid-state circuits · 2021Article
- A Parylene Neural Probe Array for Multi-Region Deep Brain Recordings.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2020Article
- Flexible Electrocorticography Electrode Array for Epileptiform Electrical Activity Recording under Glutamate and GABA Modulation on the Primary Somatosensory Cortex of Rats.Micromachines · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Obtaining multiple single-unit recordings in particular neural networks from behaving animals is crucial for the understanding of cognitive functions of the brain. Attaining stable, chronic recordings from the brain is also the foundation to develop effective cortical prosthetic devices. However, severe immune response caused by micromotion between stiff implants and surrounding brain tissue often limits the lifetime of penetrating, neural recording devices. To reduce the stiffness mismatch between recording devices and brain tissue, we developed a flexible, polymer based multi-electrode array for recording single neuron activities from the rat hippocampus, a major subcortical structure of the rat brain. Parylene C, a biocompatible polymer, was used as the structural and insulation material of the multi-electrode array. 64 platinum (Pt) recording electrodes were placed in groups along each shank to conform to the anatomical distribution of hippocampal principle neurons. The multi-electrode array was chronically implanted in three animals. After recovery, neural activity together with movement traces were collected from the behaving animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.