ArticleInternational wound journal2019
Use of platelet-rich plasma to facilitate wound healing.
Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04320498 (Effects of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Evaluation of cervical healing in a rat model using alginate hydrogel embedded with platelet-rich plasma.Molecular biology reports · 2026Article
- Comparative analysis of liquid and gel platelet rich plasma from apheresis and buffy coat in wound healing.Scientific reports · 2025Article
- Blood derivatives as monotherapy and combination therapy: A promising strategy for wound healing.Regenerative therapy · 2025Review
- Regenerative Nanofat Membrane Development Process.Aesthetic plastic surgery · 2025Article
- The Use of Platelet-Rich Plasma in the Treatment of Open Foot Injuries: A Case Series and Literature Review.Journal of orthopaedic case reports · 2025Article
- Surgical Explantation of an Amplatzer Device for Patent Foramen Ovale Closure in a Patient With Nickel Allergy: A Case Report.Clinical case reports · 2024Article
- Systematic Review of Platelet-Rich Plasma in Medical and Surgical Specialties: Quality, Evaluation, Evidence, and Enforcement.Journal of clinical medicine · 2024Review
- Review
- Decoding the Decade: Exploring the Efficacy of Platelet-Rich Plasma (PRP) in Complex Wound Management - A Comprehensive Study.Indian journal of orthopaedics · 2024Article
- The Application of Blood Products in Plastic Surgery: A Systematic Review.Plastic and reconstructive surgery. Global open · 2024Article
- Molybdesum selenide-based platelet-rich plasma containing carboxymethyl chitosan/polyvinyl pyrrolidone composite antioxidant hydrogels dressing promotes the wound healing.Journal of nanobiotechnology · 2024Article
- Research trends on platelet-rich plasma in the treatment of wounds during 2002-2021: A 20-year bibliometric analysis.International wound journal · 2023Article
- Convergence of Biofabrication Technologies and Cell Therapies for Wound Healing.Pharmaceutics · 2022Review
- The efficacy and safety of platelet-rich plasma in the tendon-exposed wounds: a preliminary study.Journal of orthopaedic surgery and research · 2022Article
- Comparison effects of platelet-rich plasma on healing of infected and non-infected excision wounds by the modulation of the expression of inflammatory mediators: experimental research.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Platelet Derivatives and the Immunomodulation of Wound Healing.International journal of molecular sciences · 2022Review
- Recent advances of the nanocomposite hydrogel as a local drug delivery for diabetic ulcers.Frontiers in bioengineering and biotechnology · 2022Review
- Investigating the effect of age on platelet ultrastructure using transmission electron microscopy.International wound journal · 2019Article
- Use of platelet-rich plasma to facilitate wound healing.International wound journal · 2019Article
- Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes.Biomaterials science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Platelet-rich plasma (PRP) is widely used nowadays in different fields of medicine, affecting physiological processes including tissue regeneration. The use of PRP in maxillofacial surgical interventions and its efficiency in the improvement of postoperative wound healing were analysed. Patients undergoing plastic and reconstructive surgeries in the maxillofacial region were recruited: 50 patients were enrolled into a control group (received no PPRP injection) and 50 patients were enrolled into a treatment group, where PRP was applied during the surgical procedure. Evaluation of treatment outcomes was carried out by determination of IL-1β, TNFα, and IL-6 cytokines levels in the wound-drain fluid. The stages of wound healing were assessed by cytological analyses and ultrasound within a month period. The use of the PRP has substantially positive effects, contributing to the improvement of the healing process. In the treatment group, fibroblasts, macrophages, and collagen fibres appeared and their quantities increased earlier than when compared with control group patients. The concentration of IL-1β and TNFα in wound fluid on day 1 and day 5 after operation was higher for the treatment group as opposed to the control group, which was linked to the influence of PRP on inflammatory and granulation phases of the healing process. An ultrasound examination showed less oedema and infiltration in the tissues around the wound of the treatment group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.