Evidence map›Paper›PMID 30440008›Full record

ArticlePloS one2018

Long-term effects of smallpox vaccination on expression of the HIV-1 co-receptor CCR5 in women.

K B Beck, B L Hønge, J S Olesen, M S Petersen, S Jespersen, C Wejse, Z J da Silva, C Medina, D D S Té, B K Moeller and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

K B BeckBandim Health Project, Indepth network, Bissau, Guinea-Bissau.ORCID 0000-0002-9133-3593
B L HøngeBandim Health Project, Indepth network, Bissau, Guinea-Bissau.
J S OlesenBandim Health Project, Indepth network, Bissau, Guinea-Bissau.
M S PetersenDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
S JespersenBandim Health Project, Indepth network, Bissau, Guinea-Bissau.
C WejseBandim Health Project, Indepth network, Bissau, Guinea-Bissau.
Z J da SilvaNational HIV programme, Ministry of Health, Bissau, Guinea-Bissau.
C MedinaNational HIV programme, Ministry of Health, Bissau, Guinea-Bissau.
D D S TéNational HIV programme, Ministry of Health, Bissau, Guinea-Bissau.
B K MoellerDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
C S BennBandim Health Project, Indepth network, Bissau, Guinea-Bissau.
P AabyBandim Health Project, Indepth network, Bissau, Guinea-Bissau.
C ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Bandim Health Project · GWAarhus University Hospital · DKNational Institute of Public Health · GWStatens Serum Institut · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmallpox vaccinations were stopped globally in 1980. Recent studies have shown that in women, being smallpox vaccinated was associated with a reduced risk of HIV infection compared with not being smallpox vaccinated. At the initial infection, HIV-1 most often uses CCR5 as a co-receptor to infect the T-lymphocytes. We therefore investigated whether smallpox vaccination is associated with a down-regulation of CCR5 on the surface of peripheral T-lymphocytes in healthy women in Guinea-Bissau.

methodsWe included HIV seronegative women from Bissau, Guinea-Bissau, born before 1974, with and without a smallpox vaccination scar. Blood samples were stabilised in a TransFix buffer solution and stained for flow cytometry according to a T-cell maturation profile.

resultsNinety-seven women were included in the study; 52 with a smallpox vaccination scar and 45 without a scar. No association between smallpox vaccination scar and CCR5 expression was found in any T-lymphocyte subtype.

conclusionAmong HIV seronegative women, being smallpox vaccinated more than 40 years ago was not associated with a down-regulation of CCR5 receptors on the surface of peripheral T-lymphocytes.

Indexed as

VaccinationCase-Control StudiesFemaleGene Expression RegulationHIV-1HIV InfectionsHumansMiddle AgedReceptors, CCR5SmallpoxT-LymphocytesReceptors, CCR5

Identifiers

PMID30440008
PMCPMC6237380
OpenAlexW2900487184

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.