Evidence map›Paper›PMID 30439685›Full record

ReviewCurrent opinion in microbiology2019

Colonization of the mammalian intestinal tract by enterococci.

Leou Ismael Banla, Nita H Salzman, Christopher J Kristich

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Increasing prevalence of bacteriocin carriage in a six-year hospital cohort ofmedRxiv : the preprint server for health sciences · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Promoter DNA recognition by theFrontiers in molecular biosciences · 2023
    Article
  12. Article
  13. Article
  14. Proteomic Characterization of Virulence Factors and Related Proteins inInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Article
  17. Microorganisms · 2021
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leou Ismael BanlaDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Nita H SalzmanDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: nsalzman@mcw.edu.
Christopher J KristichDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: ckristich@mcw.edu.

Funding

Intestinal Enterococcal Dynamics: Modeling Host-Commensal and Host-Pathogen InteractionsR35GM122503 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H · 2017 to 2021
$2.7M
Bacterial-host dynamics at the intestinal mucosal interfaceR01GM099526 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H · 2012 to 2015
$1.4M
Role of a cell wall assembly factor in enterococcal antimicrobial resistanceR21AI128219 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI KRISTICH, CHRISTOPHER J · 2017 to 2018
$424k
Genes of unknown function impacting antimicrobial resistance in enterococciR21AI132927 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI KRISTICH, CHRISTOPHER J · 2017 to 2018
$424k
Bacteriophage to prevent infection by antibiotic-resistant enterococciR21AI121552 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI KRISTICH, CHRISTOPHER J · 2016 to 2017
$418k
NIAID NIH HHS R21 AI121552NIAID NIH HHS R21 AI128219NIAID NIH HHS R21 AI132927NIGMS NIH HHS R01 GM099526NIGMS NIH HHS R35 GM122503
6 · The paper itself

Abstract

Enterococci are colonizers of the mammalian gastrointestinal tract (GIT) and normally live in healthy association with their human host. However, enterococci are also major causes of healthcare-acquired infections, prompting the US Centers for Disease Control and Prevention to declare vancomycin-resistant enterococci (VRE) a serious threat to public health. Because of both intrinsic and acquired antibiotic resistance, enterococci proliferate in the GIT during antibiotic therapy, leading to dissemination and disease. The recognition that colonization of the GIT is a pre-requisite for enterococcal infections has prompted research to study mechanisms used by enterococci to colonize this niche. This review discusses major findings of recent research to understand GIT colonization by enterococci using diverse experimental models, each of which exhibits unique strengths. This work has revealed enterococcal transcriptional reprogramming in the GIT, contributions of specific enterococcal genes encoded by the core genome to GIT colonization, the impact of genome plasticity, and roles for intra-species and inter-species interactions in modulation of GIT colonization.

Indexed as

Host-Pathogen InteractionsCarrier StateEnterococcusGram-Positive Bacterial InfectionsHumansIntestines

Identifiers

PMID30439685
PMCPMC6511500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.