ArticleJournal of affective disorders2019
Longitudinal decreases in suicidal ideation are associated with increases in salience network coherence in depressed adolescents.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of MRI Studies and the "Emotional paiN and social Disconnect (END)" Brain Model of Suicidal Behavior in Youth.Behavioural neurology · 2023Pooled it
- A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda.European journal of psychotraumatology · 2022Pooled it
- Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.BMC psychiatry · 2023Trial
- Growth Trajectories of Suicide Ideation and Attempt in a Population-Based Cohort from the United States.Archives of suicide research : official journal of the International Academy for Suicide Research · 2026Article
- Childhood gut microbiome is linked to internalizing symptoms at school age via the functional connectome.Nature communications · 2025Observational
- Longitudinal analysis of brain functional connectivity and its association with clinical assessment in depressed patients using resting state fMRI.Scientific reports · 2025Article
- Testing an interpersonal risk pathway to suicidal ideation in adolescence: linking neural, psychological, and sociometric indices of socially relevant factors.Social cognitive and affective neuroscience · 2025Article
- Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care.Translational psychiatry · 2024Article
- Neural correlates of depression-related smartphone language use in adolescents.NPP - digital psychiatry and neuroscience · 2024Article
- Brain signatures in children who contemplate suicide: learning from the large-scale ABCD study.Psychological medicine · 2023Article
- Cortical hierarchy disorganization in major depressive disorder and its association with suicidality.Frontiers in psychiatry · 2023Article
- Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback.Brain sciences · 2022Article
- Dissociating default mode network resting state markers of suicide from familial risk factors for depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Brain cortical and subcortical morphology in adolescents with depression and a history of suicide attempt.Journal of psychiatry & neuroscience : JPN · 2021Article
- Multimodal Neuroimaging of Suicidal Thoughts and Behaviors in a U.S. Population-Based Sample of School-Age Children.The American journal of psychiatry · 2021Article
- Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth.Biological psychiatry · 2021Review
- Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression.Translational psychiatry · 2021Article
- New Methods for Assessing Rapid Changes in Suicide Risk.Frontiers in psychiatry · 2021Review
- Higher Executive Control Network Coherence Buffers Against Puberty-Related Increases in Internalizing Symptoms During the COVID-19 Pandemic.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Prospective Investigation of the Interaction Between Social Problems and Neuropsychological Characteristics on the Development of Suicide Ideation.Suicide & life-threatening behavior · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSuicidal ideation (SI) is an important predictor of suicide attempt, yet SI is difficult to predict. Given that SI begins in adolescence when brain networks are maturing, it is important to understand associations between network functioning and changes in severity of SI.
methodsThirty-three depressed adolescents were administered the Columbia-Suicide Severity Rating Scale to assess SI and completed resting-state fMRI at baseline (T1) and 6 months later (T2). We computed coherence in the executive control (ECN), default mode (DMN), salience (SN), and non-relevant noise networks and then examined the association between changes in brain network coherence and changes in SI severity from T1 to T2.
resultsA greater reduction in severity of SI was associated with a stronger increase in SN coherence from T1 to T2. There were no associations between the other networks and SI. LIMITATIONS: We cannot generalize our findings to more psychiatrically diverse samples. More time-points are necessary to understand the trajectory of SI and SN coherence change.
conclusionsOur finding that reductions in SI are associated with increases in SN coherence extends previous cross-sectional results documenting a negative association between SI severity and SN coherence. The SN is involved in coordinating activation of ECN and DMN in response to salient information. Given this regulatory role of the SN, the association between SN coherence and SI suggests that adolescents with reduced SN coherence might more easily engage in harmful thoughts. Thus, the SN may be particularly relevant as a target for treatment applications in depressed adolescents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.