Evidence map›Paper›PMID 30433830›Full record

Trial reportAnnals of the American Thoracic Society2019

Frailty and Clinical Outcomes in Chronic Obstructive Pulmonary Disease.

Cassie C Kennedy, Paul J Novotny, Nathan K LeBrasseur, Robert A Wise, Frank C Sciurba, Roberto P Benzo

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of the American Thoracic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05922202 (Influence of Frailty on Cardiovascular Events and Mortality in Patients With Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 86 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05922202 recruitingnot on this mapstarted 2024, after this paper: background citation

Influence of Frailty on Cardiovascular Events and Mortality in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Multicentre Observational Study.

TypeobservationalSponsorAzienda Ospedaliero-Universitaria di ModenaRan2024 to 2026Enrolled300ConditionsRole of Frailty in COPDArmsAssessment of cardiovascular events, cardiovascular mortality, all-cause mortality, and mortality due to COPD at 12 and 24 months
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cassie C Kennedy1 Division of Pulmonary and Critical Care Medicine.
Paul J Novotny3 Health Sciences Research-Biomedical Statistics and Informatics, and.
Nathan K LeBrasseur4 Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota.
Robert A Wise5 Division of Pulmonary and Critical Care Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland; and.
Frank C Sciurba6 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Roberto P Benzo1 Division of Pulmonary and Critical Care Medicine.

Funding

Impact of CPAP on Functional Outcomes in Milder OSAR01HL076101 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEAVER, TERRI ELIZABETH · 2003 to 2006
$2.6M
Multicomponent Intervention to Decrease COPD-Related HospitalizationsR01HL094680 · NHLBI · MAYO CLINIC ROCHESTER · PI BENZO, ROBERTO PABLO · 2010 to 2014
$2.1M
Modeling of Lung HIV Cytokine/Chemokine NetworksR01HL076114 · NHLBI · BOSTON MEDICAL CENTER · PI SKOLNIK, PAUL R · 2003 to 2006
$1.8M
Training Program in Academic Pulmonary MedicineT32HL076118 · NHLBI · EMORY UNIVERSITY · PI HART, C MICHAEL · 2004 to 2013
$1.7M
Neurotrophins and Development of Baroreceptor Pathways.R01HL076113 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BALKOWIEC, AGNIESZKA Z · 2005 to 2009
$1.5M
CLINICAL COORDINATING CENTER FOR LVRS-N01HR76119-268076119-268076119N01HR076119 · HR · JOHNS HOPKINS UNIVERSITY · PI PIANTADOSI, STEVEN · 1997 to 2006
$871k
Exploring the Unmeasured Risk and Treating the Untreated Prognostic Factor: Towards Candidate Optimization in Heart and Lung TransplantK23HL128859 · NHLBI · MAYO CLINIC ROCHESTER · PI KENNEDY, CASSIE COLLEEN · 2016 to 2020
$854k
Mechanistic Effects of Health Coaching to reduce COPD HospitalizationsK24HL138150 · NHLBI · MAYO CLINIC ROCHESTER · PI BENZO, ROBERTO PABLO · 2018 to 2022
$602k
Cardiovascular Development and Disease in the YoungT32HL076116 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROSEN, MICHAEL R. · 2004 to 2008
$577k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076118 · HR · UNIVERSITY OF WASHINGTON · PI ALBERT, RICHARD K · 1997 to 2000
$225k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076113 · HR · UNIVERSITY OF PENNSYLVANIA · PI KAISER, LARRY · 1997 to 2000
$208k
CLNICAL CENTER FOR LVRSN01HR076104 · HR · CEDARS-SINAI MEDICAL CENTER · PI MCKENNA, RICHARD · 1997 to 2000
$153k
NHLBI NIH HHS K23 HL128859NHLBI NIH HHS K24 HL138150NHLBI NIH HHS N01 HR076101NHLBI NIH HHS N01 HR076102NHLBI NIH HHS N01 HR076103NHLBI NIH HHS N01 HR076104NHLBI NIH HHS N01 HR076105NHLBI NIH HHS N01 HR076106NHLBI NIH HHS N01 HR076107NHLBI NIH HHS N01 HR076108NHLBI NIH HHS N01 HR076109NHLBI NIH HHS N01 HR076110NHLBI NIH HHS N01 HR076111NHLBI NIH HHS N01 HR076112NHLBI NIH HHS N01 HR076113NHLBI NIH HHS N01 HR076114NHLBI NIH HHS N01 HR076115NHLBI NIH HHS N01 HR076116NHLBI NIH HHS N01 HR076118NHLBI NIH HHS N01 HR076119NHLBI NIH HHS R01 HL094680
6 · The paper itself

Abstract

rationaleFrailty represents an increased vulnerability to adverse health outcomes. The frailty phenotype conceptual model (three or more patient attributes of wasting, exhaustion, low activity, slowness, and weakness) is associated with increased morbidity and mortality in geriatric populations.

objectivesOur objective was to describe the risks associated with frailty in patients with chronic obstructive pulmonary disease.

methodsData from the National Emphysema Treatment Trial (NETT) were retrospectively analyzed. The frailty phenotype conceptual model was operationalized as three or more frailty parameters (a body mass index decrease of ≥5% over 12 months, self-reported exhaustion, low 6-minute walk distance, or physical activity or respiratory muscle strength in the lowest quartile). Frail participants were compared with participants with two or fewer frailty parameters. Participants were followed starting 12 months after NETT randomization (to minimize surgical effect) for 24 months. Univariate, multivariate, Kaplan-Meier, and Cox proportional hazard analyses were performed, adjusting for treatment arm, age, modified Medical Research Council dyspnea scale, sex, and baseline forced expiratory volume in 1 second (FEV

resultsThe participants (N = 902) were predominantly white (94.5%) males (59.5%), with a median age of 67 years (interquartile range, 63-70 yr) and a median FEV

conclusionsAmong adults with chronic obstructive pulmonary disease, our measure of frailty (modified from the Fried frailty phenotype) was associated with incident and longer-duration hospitalization, and with poor quality of life.

Indexed as

AgedFemaleForced Expiratory VolumeFrail ElderlyHospitalizationHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveQuality of LifeRetrospective StudiesSurveys and QuestionnairesSurvival AnalysisUnited StatesWalk TestCOPDfrailtyhospitalizationsquality of lifesurvival

Identifiers

PMID30433830
PMCPMC6376949

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.