ArticleThe Plant journal : for cell and molecular biology2019
Transcriptional profiling identifies critical steps of cell cycle reprogramming necessary for Plasmodiophora brassicae-driven gall formation in Arabidopsis.
Article in The Plant journal : for cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Metabolomics and Transcriptomics Reveal the Function of Trigonelline and Its Synthesis Gene BrNANMT in Clubroot Susceptibility of Brassica rapa.Plant, cell & environment · 2026Article
- Plant Metabolites Screening Identifies 7-epi-10-Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nuclear SnRK1 Activity Delays Clubroot Development in Arabidopsis by Reducing Sink Strength.Plant, cell & environment · 2026Article
- Growth under pressure: The pros and cons of polyploidy induced by stress.Proceedings of the National Academy of Sciences of the United States of America · 2026Review
- Under the Cover of Darkness: A Transcriptomic Exploration of Clubroot During the Night.Plant direct · 2026Article
- Transcriptional evidence of pluripotency during development of the leaf gall formed by grape phylloxera (Daktulosphaira vitifoliae).The New phytologist · 2025Article
- Laser dissection-assisted phloem transcriptomics highlights the metabolic and physiological changes accompanying clubroot disease progression in oilseed rape.The Plant journal : for cell and molecular biology · 2025Article
- Comprehensive review ofFrontiers in microbiology · 2025Review
- The Complex Roles of Plant Hormones During Clubroot Disease Development in the Brassicaceae.Journal of plant growth regulation · 2025Review
- Integration analysis of ATAC-seq and RNA-seq provides insight into fatty acid biosynthesis in Schizochytrium limacinum under nitrogen limitation stress.BMC genomics · 2024Article
- Local endoreduplication of the host is a conserved process during Phytomyxea-host interaction.Frontiers in microbiology · 2024Article
- Changes in primary metabolism and associated gene expression during host-pathogen interaction in clubroot resistance of Brassica napus.PloS one · 2024Article
- Transcriptome-based WGCNA reveals the molecular regulation of xylem plasticity in acclimation to drought and rewatering in mulberry.Frontiers in plant science · 2024Article
- Phagocytosis underpins the biotrophic lifestyle of intracellular parasites in the class Phytomyxea (Rhizaria).The New phytologist · 2023Article
- The clubroot pathogen Plasmodiophora brassicae: A profile update.Molecular plant pathology · 2023Review
- What Can We Learn from -Omics Approaches to Understand Clubroot Disease?International journal of molecular sciences · 2022Review
- Mapping of a novel clubroot disease resistance locus inFrontiers in plant science · 2022Article
- Molecular Pathotyping ofPathogens (Basel, Switzerland) · 2021Review
- Article
- A sustainedPlant signaling & behavior · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmodiophora brassicae is a soil-borne biotroph whose life cycle involves reprogramming host developmental processes leading to the formation of galls on its underground parts. Formation of such structures involves modification of the host cell cycle leading initially to hyperplasia, increasing the number of cells to be invaded, followed by overgrowth of cells colonised by the pathogen. Here we show that P. brassicae infection stimulates formation of the E2Fa/RBR1 complex and upregulation of MYB3R1, MYB3R4 and A- and B-type cyclin expression. These factors were previously described as important regulators of the G2-M cell cycle checkpoint. As a consequence of this manipulation, a large population of host hypocotyl cells are delayed in cell cycle exit and maintained in the proliferative state. We also report that, during further maturation of galls, enlargement of host cells invaded by the pathogen involves endoreduplication leading to increased ploidy levels. This study characterises two aspects of the cell cycle reprogramming efforts of P. brassicae: systemic, related to the disturbance of host hypocotyl developmental programs by preventing cell cycle exit; and local, related to the stimulation of cell enlargement via increased endocycle activity.
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