Evidence map›Paper›PMID 30431100›Full record

ArticleMolecular medicine reports2019

Genistein attenuates renal fibrosis in streptozotocin‑induced diabetic rats.

Qiang Jia, Rui Yang, Xiao-Fen Liu, Shan-Feng Ma, Lei Wang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qiang JiaDepartment of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Rui YangDepartment of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Xiao-Fen LiuDepartment of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Shan-Feng MaDepartment of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Lei WangDepartment of Physiology, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate the antifibrogenic effects of genistein (GEN) on the kidney in streptozotocin (STZ)‑induced diabetic rats and to determine the associated mechanisms. Rats were randomized into four groups: Normal control (N), STZ (S), L (STZ + low‑dose GEN) and H (STZ + high‑dose GEN). After 8 weeks, the fasting blood glucose (FBG) level, the ratio of kidney weight to body weight (renal index), 24‑h urine protein, blood urea nitrogen (BUN), serum creatinine (SCr), renal total antioxidant capacity (T‑AOC), superoxide dismutase (SOD), lipid peroxidation (LPO), malondialdehyde (MDA) and hydroxyproline (Hyp) contents were measured. The histomorphology and ultrastructure of the kidney were also assessed. In addition, mRNA expression levels of transforming growth factor‑β1 (TGF‑β1) and protein expression levels of nuclear factor erythroid 2‑related factor 2 (Nrf2), heme oxygenase‑1 (HO‑1), NAD(P)H:quinone oxidoreductase 1 (NQO1), TGF‑β1, mothers against decapentaplegic homolog 3 (Smad3), phosphorylated (p)‑Smad3 and collagen IV were estimated. Compared with group N, the levels of FBG, renal index, 24‑h urine protein, BUN, SCr, LPO, MDA and Hyp were increased, whereas the levels of T‑AOC and SOD were decreased in group S. The structure of renal tissue was damaged, and the expression of Nrf2, HO‑1 and NQO1 were reduced, whereas the expression of TGF‑β1, Smad3, p‑Smad3 and collagen IV were increased in group S. Compared with group S, the aforementioned indices were improved in groups L and H. In conclusion, GEN exhibited reno‑protective effects in diabetic rats and its mechanisms may be associated with the inhibition of oxidative stress by activating the Nrf2‑HO‑1/NQO1 pathway, and the alleviation of renal fibrosis by suppressing the TGF‑β1/Smad3 pathway.

Indexed as

AnimalsBlood Urea NitrogenCreatinineDiabetes Mellitus, ExperimentalFibrosisGenisteinKidneyKidney DiseasesLipid PeroxidationMaleMalondialdehydeNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2Oxidative StressRatsRats, Sprague-DawleyCreatinineGenisteinMalondialdehydeNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2Smad3 ProteinStreptozocinSuperoxide DismutaseTransforming Growth Factor beta1diabetes mellitusgenisteinoxidative stressransforming growth factor‑β1/mothers against decapentaplegic homolog 3 pathwayratrenal fibrosis

Identifiers

PMID30431100
PMCPMC6297769
OpenAlexW2899786776

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.