ArticleInternational journal of molecular medicine2019
Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults.
Article in International journal of molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- NLRP3 inflammasome and lipid metabolism analysis based on UPLC-Q-TOF-MS in gouty nephropathy.International journal of molecular medicine · 2019Trial
- 1,400 genetically predicted plasma metabolites in relation to risk of primary biliary cholangitis: a bi-directional, two-sample Mendelian randomization analysis.Clinical and experimental hepatology · 2025Article
- Metabolomics-based treatment for chronic diseases: results from a multidisciplinary clinical study.BMJ nutrition, prevention & health · 2024Article
- Distinct and Overlapping Metabolites Associated with Visual Impairment and Cognitive Impairment.Journal of Alzheimer's disease reports · 2024Article
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- Sex differences in the human metabolome.Biology of sex differences · 2022Review
- Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins.Environmental health : a global access science source · 2022Article
- Imbalances in TCA, Short Fatty Acids and One-Carbon Metabolisms as Important Features of Homeostatic Disruption Evidenced by a Multi-Omics Integrative Approach of LPS-Induced Chronic Inflammation in Male Wistar Rats.International journal of molecular sciences · 2022Article
- The snapshot of metabolic health in evaluating micronutrient status, the risk of infection and clinical outcome of COVID-19.Clinical nutrition ESPEN · 2021Review
- Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus.Frontiers in molecular biosciences · 2021Review
- Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Review
- Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review).Molecular medicine reports · 2020Review
- Article
- Dysregulation in PlasmaAdvances in virology · 2020Article
- Metabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective.Metabolites · 2019Article
- Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases.Frontiers in molecular biosciences · 2019Article
Corrections and comments
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Fatty acids (FAs) play critical roles in health and disease. The detection of FA imbalances through metabolomics can provide an overview of an individual's health status, particularly as regards chronic inflammatory disorders. In this study, we aimed to establish sensitive reference value ranges for targeted plasma FAs in a well‑defined population of healthy adults. Plasma samples were collected from 159 participants admitted as outpatients. A total of 24 FAs were analyzed using gas chromatography‑mass spectrometry, and physiological values and 95% reference intervals were calculated using an approximate method of analysis. The differences among the age groups for the relative levels of stearic acid (P=0.005), the omega‑6/omega‑3 ratio (P=0.027), the arachidonic acid/eicosapentaenoic acid ratio (P<0.001) and the linoleic acid‑produced dihomo‑gamma‑linolenic acid (P=0.046) were statistically significant. The majority of relative FA levels were higher in males than in females. The levels of myristic acid (P=0.0170) and docosahexaenoic acid (P=0.033) were significantly different between the sexes. The reference values for the FAs examined in this study represent a baseline for further studies examining the reproducibility of this methodology and sensitivities for nutrient deficiency detection and investigating the biochemical background of pathological conditions. The application of these values to clinical practice will allow for the discrimination between health and disease and contribute to early prevention and treatment.
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